122019-83-4Relevant academic research and scientific papers
Resolution and Determination of the Absolute Stereochemistry of α- and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases
Baek, Du-Jong,Daniels, Scott B.,Reed, Peter E.,Katzenellenbogen, John A.
, p. 3963 - 3972 (1989)
To study the enantioselectivity of alternate substrate inhibition of chymotrypsin by chiral α- and β-arylsubstituted enol lactones, we have prepared four of these lactones in homochiral form: 3-phenyl-6-methylenetetrahydro-2-pyranone (αPh6H, IIa), 3-(1-na
