Resolution and Determination of the Absolute Stereochemistry of α- and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases

DOI: 10.1021/jo00277a040

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Journal of Organic Chemistry p. 3963 - 3972 (1989)

Update date:2022-08-02

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Authors:

Baek, Du-Jong

Daniels, Scott B.

Reed, Peter E.

Katzenellenbogen, John A.

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Article abstract of DOI:10.1021/jo00277a040

To study the enantioselectivity of alternate substrate inhibition of chymotrypsin by chiral α- and β-arylsubstituted enol lactones, we have prepared four of these lactones in homochiral form: 3-phenyl-6-methylenetetrahydro-2-pyranone (αPh6H, IIa), 3-(1-na

Full text of DOI:10.1021/jo00277a040

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