Resolution and Determination of the Absolute Stereochemistry of α- and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases

DOI: 10.1021/jo00277a040

Source and publish data:

Journal of Organic Chemistry p. 3963 - 3972 (1989)

Update date:2022-08-02

Topics:

Authors:

Baek, Du-Jong

Daniels, Scott B.

Reed, Peter E.

Katzenellenbogen, John A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00277a040

To study the enantioselectivity of alternate substrate inhibition of chymotrypsin by chiral α- and β-arylsubstituted enol lactones, we have prepared four of these lactones in homochiral form: 3-phenyl-6-methylenetetrahydro-2-pyranone (αPh6H, IIa), 3-(1-na

Full text of DOI:10.1021/jo00277a040

Products guided by the article

Product name:5,6-Dibromo-3-phenyl-hexanoic acid ethyl ester

Cas No:122019-83-4

R&D Labs maybe for 122019-83-4

Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
Dongguan Albiya Energy Science and Technology Co.,Ltd

Contact:+86-769-22181286

Address:Huanan Industial Park, Dongguan,China
Shandong Zhongcheng Barium Salt Co., Ltd

Contact:+86-15725732638

Address:No.29 baoxi road, hi-tech zone, zibo, shandong
Sigma-Aldrich Chemie GmbH

website:http://www.sigmaaldrich.com

Contact:800 558-9160

Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China

Relevant to this article

Synthesis of Biginelli dihydropyrimidinone derivatives with various substituents on aluminium-planted mesoporous silica catalyst

Doi:10.1039/b920821f
(2010)
New organic derivatives of O,O'-(o-, m-, and p-ditolyl)/ dibenzyldithiophosphates: Synthesis and characterization

Doi:10.1080/10426500802445340
(2009)
Synthesis of 4′H-spiro[adamantane-2,3′-isoquinoline] derivatives

Doi:10.1134/S1070428009120264
(2009)
Decakis(2,6-diethylphenyl)decastanna[5]prismane: characterization and molecular structure

Doi:10.1021/ja00005a074
(1991)
Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as γ-aminobutyric acid_A receptor ligands: Synthesis, pharmacology, and structure-activity relationships

Doi:10.1021/jm100106r
(2010)
Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT_1A, D4.2, and α_2A receptors: Synthesis and in vitro radioligand binding studies

Doi:10.1071/CH09353
(2010)

Article Doi