Resolution and Determination of the Absolute Stereochemistry of α- and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases

DOI: 10.1021/jo00277a040

Source and publish data:

Journal of Organic Chemistry p. 3963 - 3972 (1989)

Update date:2022-08-02

Topics:

Authors:

Baek, Du-Jong

Daniels, Scott B.

Reed, Peter E.

Katzenellenbogen, John A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00277a040

To study the enantioselectivity of alternate substrate inhibition of chymotrypsin by chiral α- and β-arylsubstituted enol lactones, we have prepared four of these lactones in homochiral form: 3-phenyl-6-methylenetetrahydro-2-pyranone (αPh6H, IIa), 3-(1-na

Full text of DOI:10.1021/jo00277a040

Products guided by the article

Product name:5,6-Dibromo-3-phenyl-hexanoic acid ethyl ester

Cas No:122019-83-4

R&D Labs maybe for 122019-83-4

Shanghai Standard Biotech Co., Ltd.

Contact:+86-18502101150

Address:Room 103, Building 2nd, NO.720, Cailun Road , Pudong District, Shanghai, China
Shanghai Dano Pharmaceutical Co.,Ld.(expird)

Contact:+86-592-6266840

Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
WENZHOU M&C FOREIGN TRADE CO.,LTD.

Contact:+86-577-88862917

Address:No.8 Liming West Road,Wenzhou,zhejiang,China
HANGZHOU FOREWIN PHARMA CO., LTD

Contact:+86-571-89053961

Address:hangzhou

Relevant to this article

Synthesis of Biginelli dihydropyrimidinone derivatives with various substituents on aluminium-planted mesoporous silica catalyst

Doi:10.1039/b920821f
(2010)
New organic derivatives of O,O'-(o-, m-, and p-ditolyl)/ dibenzyldithiophosphates: Synthesis and characterization

Doi:10.1080/10426500802445340
(2009)
Synthesis of 4′H-spiro[adamantane-2,3′-isoquinoline] derivatives

Doi:10.1134/S1070428009120264
(2009)
Decakis(2,6-diethylphenyl)decastanna[5]prismane: characterization and molecular structure

Doi:10.1021/ja00005a074
(1991)
Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as γ-aminobutyric acid_A receptor ligands: Synthesis, pharmacology, and structure-activity relationships

Doi:10.1021/jm100106r
(2010)
Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT_1A, D4.2, and α_2A receptors: Synthesis and in vitro radioligand binding studies

Doi:10.1071/CH09353
(2010)

Article Doi