1220326-96-4Relevant articles and documents
Synthesis of (+)-centrolobine and its analogues by using acyl anion chemistry
Sudarshan, Kasireddy,Aidhen, Indrapal Singh
, p. 2298 - 2302 (2013/05/09)
A new route based on the use of acyl anion chemistry was developed for the synthesis of (+)-centrolobine and its analogues. Acid-catalyzed benzylic cation initiated cyclization was the key step in the stereoselective formation of the cis-2,6-disubstituted tetrahydropyran ring. The developed methodology was applied to the synthesis of (+)-centrolobine analogues containing electron-donating substituents in the aryl rings.
Synthesis of a diarylheptanoid, (+)-centrolobine
Reddy, Ch. Raji,Madhavi, P. Phani,Chandrasekhar
experimental part, p. 103 - 105 (2010/04/06)
A chiron approach for the total synthesis of (+)-centrolobine has been described from the commercially available aldehyde 3 employing an acid-catalyzed stereoselective formation of tetrahydropyran ring as the key step. The desired molecule was accomplished in eight steps with 62% overall yield.
