1451998-97-2Relevant academic research and scientific papers
Synthesis of (+)-centrolobine and its analogues by using acyl anion chemistry
Sudarshan, Kasireddy,Aidhen, Indrapal Singh
, p. 2298 - 2302 (2013/05/09)
A new route based on the use of acyl anion chemistry was developed for the synthesis of (+)-centrolobine and its analogues. Acid-catalyzed benzylic cation initiated cyclization was the key step in the stereoselective formation of the cis-2,6-disubstituted tetrahydropyran ring. The developed methodology was applied to the synthesis of (+)-centrolobine analogues containing electron-donating substituents in the aryl rings.
