122059-85-2

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 538-51-2 benzylidene phenylamine 
• 98-95-3 nitrobenzene 

Relevant academic research and scientific papers

Inverse electron demand Diels-Alder reactions of heterodienes catalyzed by potassium hydrogen sulfate: Diastereoselective, one-pot synthesis of pyranobenzopyrans, furanobenzopyrans and tetrahydroquinolines derivatives

Potassium hydrogen sulfate catalyzes the one-pot three components coupling of aldehydes, anilines, and electron rich dienophiles such as dihydropyran, dihydrofuran, ethyl vinylether, and cyclopentadiene. With o-hydroxybenzaldehyde, the reaction probably p

Urea nitrate catalyzed imino Diels-Alder reactions: Synthesis of cyclopentaquinolines, pyranoquinolines, and furoquinoline derivatives

Urea nitrate is found to be an efficient catalyst for the imino Diels-Alder reaction of aldimines with cyclopentadiene, 3,4-dihydropyran and dihydrofuran is reported for the first time. One pot synthesis of cyclopentaquinolines from benzaldehyde, aromatic

Structure–Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

Following the discovery of a type III allosteric modulator of cyclin-dependent kinase 2 (CDK2) characterized by a hexahydrocyclopenta[c]quinolone scaffold, three different series of its derivatives were synthesized and biologically evaluated. Docking of t

N-Trifluoroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline ozonides

A three-component condensation of aromatic amine, aldehyde, and cyclopentadiene with subsequent N-trifluoroacetylation leads to 4- and 4,8-substituted N-trifluoroacetyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c] quinolines. Ozonation of the double bond in the latter produced the corresponding isomeric stable ozonides having (1R*,4S*,5aR*, 6S*,11bR*)-configuration and differing in inversion at the carboxamide nitrogen atom.

Indium trichIoride (InCl3)catalyzed imino Diels-Alder reactions: An efficient synthesis of cyclopentaquinolines, azabicyclooctanones and azabicyclononanones

Anhydrous indium trichloride (InCl3) is found to catalyze the imino Diels-Alder reactions of Schiff's bases with cyclopentadiene, cyclohexen-2-one and cyclohepten-2-one which resulted in facile synthesis of cyclopentaquinolines, azabicyclooctanones and previously unreported series of azabicyclononanones.

Expanding the tetrahydroquinoline pharmacophore

Tetrahydroquinoline is a privileged scaffold with a large number of biological applications. The tetrahydroquinoline pharmacophore has been expanded to yield 34 compounds. Biological screening of these compounds led to the identification of tetrahydroquin

Imino Diels-Alder reactions catalyzed by oxalic acid dihydrate. Synthesis of Tetrahydroquinoline derivatives

Oxalic acid dihydrate is found to catalyze the Imino Diels-Alder reaction of schiff bases derived from substituted anilines with cyclopentadiene, results in the formation of Tetrahydroquinoline derivatives in moderate yields.

From nitrobenzenes to substituted tetrahydroquinolines in a single step by a domino reduction/imine formation/aza-diels-alder reaction

The three-component reaction between a nitrobenzene, an aldehyde, and a dienophile in the presence of iron powder as a reductant and montmorillonite K10 as a catalyst in aqueous citric acid delivers the products of an aza-Diels-Alder (Povarov) reaction with high endo-selectivity and yields up to 99%.

Natural product inspired diversity oriented synthesis of tetrahydroquinoline scaffolds as antitubercular agent

An efficient natural product inspired diversity oriented syn thesis of tetrahydroquinoline analogues has been developed using the natural carbohydrate derived solid acid catalyst via multicomponent aza-Diels-Alder reaction of imine (generated in situ from

Recyclable polymeric π-acid catalyst effective in aqueous and solvent-free inverse-electron-demand aza-Diels-Alder reactions

A polymer-supported π-acid (poly-DCKA-1) was found to be a highly efficient and recyclable catalyst in two- and three-component inverse-electron-demand aza-Diels-Alder reactions at room temperature not only in water but also under solvent-free conditions.