122059-86-3

Usage

Uses

Used in Pharmaceutical Industry:
(3aR,4S,9bS)-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic is used as a potential pharmaceutical candidate for the development of new drugs. Its unique molecular structure and functional groups may offer novel therapeutic properties, making it a valuable compound for medicinal chemistry research and drug discovery.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (3aR,4S,9bS)-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic serves as a promising compound for the investigation of its potential biological activities and interactions with biological targets. Its structural features may provide insights into the design of new drugs with improved efficacy and selectivity.

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 3939-41-1 4-(benzylideneimino)benzoic acid 
• 100-52-7 benzaldehyde 
• 150-13-0 4-amino-benzoic acid 
• 3939-41-1 N-(4-carboxyphenyl)benzylideneimine 
• 62-23-7 4-nitro-benzoic acid 

Relevant academic research and scientific papers

Solid support synthesis of tetrahydroquinolines via the Grieco three component condensation

A three component condensation involving aromatic amines, aldehydes, alkenes and TFA as a catalyst affords the desired tetrahydroquinolines in good yields. A variety of structures for the olefin and aldehyde inputs in the library were investigated.

Inter- and Intramolecular Imino Diels-Alder Reactions Catalyzed by Sulfamic Acid: A Mild and Efficient Catalyst for a One-Pot Synthesis of Tetrahydroquinolines

The successful use of sulfamic acid as a catalyst in the inter- and intramolecular Inverse Electron Demand Diels-Alder reactions of iminodienes is described. A one-pot synthesis of tetrahydroquinolines was achieved by three component coupling of benzaldeh

Inverse electron demand Diels-Alder reactions of heterodienes catalyzed by potassium hydrogen sulfate: Diastereoselective, one-pot synthesis of pyranobenzopyrans, furanobenzopyrans and tetrahydroquinolines derivatives

Potassium hydrogen sulfate catalyzes the one-pot three components coupling of aldehydes, anilines, and electron rich dienophiles such as dihydropyran, dihydrofuran, ethyl vinylether, and cyclopentadiene. With o-hydroxybenzaldehyde, the reaction probably p

Urea nitrate catalyzed imino Diels-Alder reactions: Synthesis of cyclopentaquinolines, pyranoquinolines, and furoquinoline derivatives

Urea nitrate is found to be an efficient catalyst for the imino Diels-Alder reaction of aldimines with cyclopentadiene, 3,4-dihydropyran and dihydrofuran is reported for the first time. One pot synthesis of cyclopentaquinolines from benzaldehyde, aromatic

Triphenyl phosphonium perchlorate - An efficient catalyst for the imino Diels-Alder reaction of imines with electron rich dienophiles. Synthesis of pyranoquinoline, furoquinoline and phenanthridine derivatives

Triphenyl phosphonium perchlorate (TPP) is found to be an efficient catalyst for the imino Diels-Alder reaction of aldimines with cyclopentadiene and 3,4-dihydro-2H-pyran is reported for the first time. One pot synthesis of furoquinoline, cyclopentaquinol

Imino Diels-Alder reactions catalyzed by oxalic acid dihydrate. Synthesis of Tetrahydroquinoline derivatives

Oxalic acid dihydrate is found to catalyze the Imino Diels-Alder reaction of schiff bases derived from substituted anilines with cyclopentadiene, results in the formation of Tetrahydroquinoline derivatives in moderate yields.

ROLE REVERSAL IN THE CYCLOCONDENSATION OF CYCLOPENTADIENE WITH HETERODIENOPHILES DERIVED FROM ARYL AMINES AND ALDEHYDES: SYNTHESIS OF NOVEL TETRAHYDROQUINOLINES

Immonium ions derived from aryl amines and aldehydes function not as heterodienophiles but rather as heterodienes in the presence of cyclopentadiene giving rise to novel tetrahydroquinolines.