1221157-00-1

Basic information

• Product Name: 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane
• Synonyms: 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane
• CAS NO: 1221157-00-1
• Molecular Weight: 332.397
• Mol File: 1221157-00-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane(1221157-00-1)
• EPA Substance Registry System: 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane(1221157-00-1)

Safety Data

• Hazardous Substances Data: 1221157-00-1(Hazardous Substances Data)

Upstream product

• 26691-25-8 3-(benzyloxy)-4-ethoxybenzaldehyde 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 50773-56-3 3-benzyloxy-4-hydroxybenzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1221156-99-5 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene 
• 52987-93-6 2-(4-ethoxy-3-methoxyphenyl)-1,3-dioxolane 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 2539-53-9 4-ethoxy-3-hydroxybenzaldehyde 
• 121-33-5 vanillin 

Downstream Products

• 1334725-14-2 C₃₃H₃₇O₈P 
• 1221226-35-2 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenol phosphate 

Relevant articles and documents

5-FLUOROURACIL DERIVATIVES, PREPARATION METHODS AND USES THEREOF

Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.

Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs

Abstract A total of 11 novel combretastatin A-4 (CA-4) analogs were designed, synthesized, and evaluated for the anti-proliferative effects in tumor cells. The compounds represent four structural classes: (i) hydrogenated derivatives, (ii) ethoxyl derivatives, (iii) amino derivatives and (iv) pro-drugs. Biological evaluations demonstrate that multiple structural features control the biological potency. Three of the compounds, sit-1, sit-2 and sit-3, have potent anti-proliferative activity against multiple cancer cell lines. Their pro-drugs were synthesized to increase water solubility. Structure-activity relationship study and Surflex-Docking were studied in this paper. These results will be useful for the design of new CA-4 analogs that are structurally related to the SAR study.