26691-25-8

Basic information

• Product Name: 3-(BENZYLOXY)-4-ETHOXYBENZALDEHYDE
• Synonyms: 3-(BENZYLOXY)-4-ETHOXYBENZALDEHYDE
• CAS NO: 26691-25-8
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.3
• Mol File: 26691-25-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(BENZYLOXY)-4-ETHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BENZYLOXY)-4-ETHOXYBENZALDEHYDE(26691-25-8)
• EPA Substance Registry System: 3-(BENZYLOXY)-4-ETHOXYBENZALDEHYDE(26691-25-8)

Safety Data

• Hazardous Substances Data: 26691-25-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 74-96-4 ethyl bromide 
• 50773-56-3 3-benzyloxy-4-hydroxybenzaldehyde 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 52987-93-6 2-(4-ethoxy-3-methoxyphenyl)-1,3-dioxolane 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 2539-53-9 4-ethoxy-3-hydroxybenzaldehyde 
• 584-08-7 potassium carbonate 
• 100-44-7 benzyl chloride 

Downstream Products

• 1221156-99-5 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene 
• 1221157-00-1 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane 
• 1334725-14-2 C₃₃H₃₇O₈P 
• 1622205-43-9 tert-butyl 4-(4-((4-((6-ethoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl) carbamoyl)phenyl)piperidine-1-carboxylate 
• 1622205-38-2 (E)-2-(benzyloxy)-1-ethoxy-4-(2-nitrovinyl)benzene 
• 1622204-15-2 6-ethoxy-5-((2-(4-(1-ethylpiperidin-4-yl)benzamide)pyridin-4-yl)oxy)-N-methyl-1H-indole-1-carboxamide 
• 1622204-14-1 6-ethoxy-N-methyl-5-((2-(4-(piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide 
• 26691-30-5 6'-Ethoxy-4,5-dimethoxy-2,3'-bis(methoxycarbonylmethyl)phenoxybenzol 
• 26691-27-0 methyl (3-benzyloxy-4-ethoxyphenyl)acetate 
• 26691-29-2 methyl (4-ethoxy-3-hydroxyphenyl)acetate 
• 26691-28-1 4-Ethoxy-3-hydroxyphenylessigsaeure 
• 26691-26-9 4-(3-benzyloxy-4-ethoxy-benzylidene)-2-phenyl-4H-oxazol-5-one 

Relevant articles and documents

Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs

Abstract A total of 11 novel combretastatin A-4 (CA-4) analogs were designed, synthesized, and evaluated for the anti-proliferative effects in tumor cells. The compounds represent four structural classes: (i) hydrogenated derivatives, (ii) ethoxyl derivatives, (iii) amino derivatives and (iv) pro-drugs. Biological evaluations demonstrate that multiple structural features control the biological potency. Three of the compounds, sit-1, sit-2 and sit-3, have potent anti-proliferative activity against multiple cancer cell lines. Their pro-drugs were synthesized to increase water solubility. Structure-activity relationship study and Surflex-Docking were studied in this paper. These results will be useful for the design of new CA-4 analogs that are structurally related to the SAR study.

ETHOXY DIPHENYL ETHANE DERIVATES, PREPARATION PROCESSES AND USES THEREOF

The invention discloses an ethoxydiphenylethane derivative and a synthetic method and uses thereof 4' position of phenylethane B aromatic ring is chemically modified by ethoxy and hydroxy at position 3' thereof is simultaneously modified to water soluble prodrug such as phosphate, and similarly, amino acid side chain is introduced to amino at position 3' to form amino acid amide water soluble prodrug having the structure shown as formula (I) the ethoxydiphenylethane derivative and the prodrug thereof include strong tubulin aggregation inhibiting ability and obvious target damage effect for tumor vessels, selectively cause dysfunction and structural damage of tumor vessels and induce apoptosis of vascular endothelial cells in order to play the role of killing tumor cells or inhibiting tumor metastasis in case that the tumor cells are free from the support of nutrition and oxygen.