1221290-92-1

Basic information

• Product Name: N-{2-[4-(2-methylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide
• CAS NO: 1221290-92-1
• Molecular Weight: 374.486
• Mol File: 1221290-92-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{2-[4-(2-methylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[4-(2-methylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide(1221290-92-1)
• EPA Substance Registry System: N-{2-[4-(2-methylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide(1221290-92-1)

Safety Data

• Hazardous Substances Data: 1221290-92-1(Hazardous Substances Data)

Upstream product

• 84741-86-6 quinoline-3-carbonyl chloride 
• 58334-09-1 2-(4-o-tolyl-piperazin-1-yl)-ethylamine 

Relevant articles and documents

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.