1221349-39-8

Basic information

• Product Name: 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
• Synonyms: 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene
• CAS NO: 1221349-39-8
• Molecular Weight: 397.424
• Mol File: 1221349-39-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene(1221349-39-8)
• EPA Substance Registry System: 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene(1221349-39-8)

Safety Data

• Hazardous Substances Data: 1221349-39-8(Hazardous Substances Data)

Upstream product

• 1192-37-6 methylenecyclohexane 
• 89466-07-9 4-amino-3-nitrophenylboronic acid 
• 1259026-33-9 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid chloride 
• 1015770-72-5 1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid 
• 1259026-50-0 2'-(difluoromethoxy)-3-nitro-[1,1'-biphenyl]-4-amine 
• 1015770-74-7 1-oxa-2-aza-spiro[4.5]dec-2-ene-3-carboxylic acid ethyl ester 
• 175278-33-8 1-bromo-2-(dilfluoromethoxy)benzene 

Downstream Products

• 1259026-79-3 3-[5-(2-difluoromethoxyphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride 

Relevant articles and documents

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel that is thermoresponsive to cool to cold temperatures (8-28 ° C) and also may be activated by chemical agonists such as menthol and icilin. Antagonism of TRPM8 activation i