122136-03-2Relevant academic research and scientific papers
CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS
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, (2020/03/29)
The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.
3-cyano-4-alcoholate benzoate synthesis method
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Paragraph 0025; 0027-0030; 0043-0047, (2018/07/30)
The invention discloses a 3-cyano-4-alcoholate benzoate synthesis method. The general formula for the reaction is shown in the description, wherein R1 is isopropyl or other alkyls, and R2 is alkyl. The reaction condition of the method is mild, the raw materials are easy to get, the yield is high, the post-processing is simple, and the method provides an important reference for the industrial production.
Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation
Hada, Kihito,Suda, Atsushi,Asoh, Kohsuke,Tsukuda, Takuo,Hasegawa, Masami,Sato, Yasuko,Ogawa, Kotaro,Kuramoto, Shino,Aoki, Yuko,Shimma, Nobuo,Ishikawa, Tsutomu,Koyano, Hiroshi
experimental part, p. 1442 - 1460 (2012/04/17)
Proliferation of endothelial cells is critical for angiogenesis. We report orally available, in vivo active antiangiogenic agents which specifically inhibit endothelial cell proliferation. After identifying human umbilical vein endothelial cell (HUVEC) pr
BENZAMIDE DERIVATIVE
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Page/Page column 41-42, (2010/11/23)
To provide compounds which have high angiogenesis inhibiting activity, and are useful as agents for effective treatment and prevention of diseases involving pathologic angiogenesis, for example, cancer and cancer metastasis, methods for producing the comp
An efficient one-pot synthesis of pyrrolo[4,3,2-ij]isoquinoline derivatives by a consecutive aza-wittig/electrocyclic ring-closure/intramolecular acylation process
Molina,Alajarin,Vidal
, p. 293 - 296 (2007/10/02)
Iminophosphorane, ethyl 5-ethoxycarbonyl-2-methoxy-α-[(triphenylphosphoranylidene)amino]cinn amate (4) reacts with aliphatic and aromatic isocyanates in toluene at 170°C to give directly the corresponding pyrrolo[4,3,2-ij]isoquinolines 8 in moderate yields.
