122148-92-9Relevant academic research and scientific papers
Diastereoselective synthesis of a hydroxamate containing bicyclo-[3.2.0] β-lactam aminal via ruthenium alkene isomerization and Pd(II)-catalyzed oxidative amidation
Jobbins, Maria O.,Majewski, Mark W.,Oliver, Allen G.,Miller, Marvin J.
, p. 3141 - 3143 (2015)
With antibiotic resistance on the rise, the need for new medicinal scaffolds is needed. The synthesis of an aminal bicyclic β-lactam core is described. The key synthetic step is Pd(II)-catalyzed oxidative amidation. The product is a single diastereomer, c
Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles
Barrios, Francis J.,Springer, Brannon C.,Hazlitt, Robert A.,Colby, David A.
, p. 175 - 180 (2015/05/05)
Disubstituted hydroxylamines are synthesized and used to form aluminum-amide complexes. These reagents mask carbonyl groups in situ via nucleophilic addition. The stability and utility of the aluminum-aminals are presented in the context of selectively controlling nucleophilic addition on substrates with multiple carbonyl groups.
Syntheses of hydroxamic acid-containing bicyclic β-lactams via palladium-catalyzed oxidative amidation of alkenes
Jobbins, Maria O.,Miller, Marvin J.
, p. 1620 - 1625 (2014/03/21)
Palladium-catalyzed oxidative amidation has been used to synthesize hydroxamic acid-containing bicyclic β-lactam cores. Oxidative cleavage of the pendant alkene provides access to the carboxylic acid in one step.
Rational design, synthesis, and evaluation of tetrahydroxamic acid chelators for stable complexation of zirconium(IV)
Guerard, Francois,Lee, Yong-Sok,Brechbiel, Martin W.
supporting information, p. 5584 - 5591 (2014/05/20)
Metals of interest for biomedical applications often need to be complexed and associated in a stable manner with a targeting agent before use. Whereas the fundamentals of most transition-metal complexation processes have been thoroughly studied, the compl
TETRAHYDROXAMATE CHELATORS OF ZIRCONIUM89 AND NIOBIUM90 FOR USE IN DIAGNOSTIC APPLICATIONS
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Paragraph 0083-0084; sheet 2, (2014/10/18)
Disclosed is a compound of formula (I) or (II) in which R1-R4, R1,-R5,, Z1+-Z4, and Z1,-Z4, are as described herein. Also disclosed are a 89Zr- or 90/
Lewis acid-mediated radical cyclization: Stereocontrol in cascade radical addition-cyclization-trapping reactions
Miyabe, Hideto,Asada, Ryuta,Takemoto, Yoshiji
, p. 3519 - 3530 (2012/05/20)
An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good en
Polarity-mismatched addition of electrophilic carbon radicals to an electron-deficient acceptor: Cascade radical addition-cyclization-trapping reaction
Yoshioka, Eito,Kohtani, Shigeru,Sawai, Kaori,Kentefu,Tanaka, Eri,Miyabe, Hideto
, p. 8588 - 8604,17 (2020/09/15)
The polarity-mismatched perfluoroalkyl radical addition to electron-deficient alkenes was studied. For this study, several substrates having two polarity-different radical acceptors were employed to investigate the regiochemical courses of cascade reactio
Synthesis of the reported structure of the naturally occurring siderophore nocardimicin B
Banks, James C.,Moody, Christopher J.
scheme or table, p. 3371 - 3373 (2009/08/17)
A total synthesis of the reported structure of the naturally occurring siderophore nocardimicin B is reported: the synthetic material appears to be diastereomeric with the natural product.
Enantioselective cascade radical addition-cyclization-trapping reactions
Miyabe, Hideto,Asada, Ryuta,Toyoda, Akira,Takemoto, Yoshiji
, p. 5863 - 5866 (2007/10/03)
(Chemical Equation Presented) In addition: The chiral Lewis acid mediated radical addition-cyclization-trapping reaction of a hydroxamate ester with two radical acceptors provides a cascade approach for the asymmetric synthesis of various γ-lactams (see s
ALKYLATION OF N-BENZYLOXYUREAS AND CARBAMATES
Sulsky, Richard,Demers, James P.
, p. 31 - 34 (2007/10/02)
N-benzyloxyureas and orthogonically protected N-hydroxycarbamates can be alkylated in high yields and subsequently deprotected to provide N-alkyl hydroxyureas and hydroxylamines.
