1221576-80-2

Upstream product

• 10531-78-9 5-methyl-1,3-benzoxazole 
• 536-74-3 phenylacetylene 
• 1483-82-5 phenylethynyl chloride 
• 932-88-7 1-iodo-2-phenylethyne 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 1221577-05-4 2-deuterio-5-methylbenzoxazole 
• 637-44-5 phenylpropyolic acid 
• 3240-11-7 Phenylacetylene-d1 

Relevant academic research and scientific papers

Palladium-catalyzed decarboxylative C-H alkynylation of benzoxazoles with α,β-ynoic acids

Palladium-catalyzed decarboxylative C-H alkynylation of benzoxazoles with α,β-ynoic acids was achieved for the first time. This straightforward method was found to be synthetically effective without strong base under air. Pd-catalyzed decarboxylative C-H alkynylation was developed through the reaction of benzoxazoles with a variety of -ynoic acids. This reaction proceeded smoothly via C-H functionalization in the presence of dppe and Ag2O without strong base under air. Copyright

Ligand and solvent-free iron catalyzed oxidative alkynylation of azoles with terminal alkynes

A highly efficient and versatile iron catalyzed oxidative alkynylation of azoles with terminal alkynes under ligand and solvent-free conditions is described.

Novel preparation method of benzoxazole derivative

The present invention relates to a method for preparing an alkynylated bezoxazole derivative represented by chemical formula 1, and more specifically, to a method for preparing an alkynylated bezoxazole derivative by reacting a silver slat, propiolic acid, and benzoxazole compounds in the presence of a palladium catalyst and 1,3-bis(diphenylphosphino)propane as a phosphine-based catalyst.

Dehydrogenative and decarboxylative C-H alkynylation of heteroarenes catalyzed by Pd(II)-carbene complex

The direct alkynylation of heteroarenes was accomplished with easily prepared Pd(II) carbene complex (Pd Cat.) by two complementary strategies. Pd Cat. catalysed cross-dehydrogenative coupling of terminal alkynes with heteroarenes was achieved in the firs

Palladium-catalyzed oxidative alkynylation of heterocycles with terminal alkynes under air conditions

Pd-Catalyzed oxidative alkynylation of azoles with terminal alkynes was developed via simultaneous activation of both heterocyclic sp2 C-H and alkynyl sp C-H bonds. The choice of palladium catalyst source and external base resulted in being imp

Highly efficient and versatile pd-catalyzed direct alkynylation of both azoles and azolines

A highly efficient and versatile Pd-catalyzed direct alkynylation reaction of heterocycles with 1-bromoalkynes was developed. The substrate scope of the reaction was very broad to include not only azoles but also azolines for the first time, thus offering an important advance in the direct functionalization of heterocycles.

Nickel- and copper-catalyzed direct alkynylation of azoles and polyfluoroarenes with terminal alkynes under O2 or atmospheric conditions

The direct C-H alkynylation of azoles with terminal alkynes proceeds efficiently under a nickel/O2 catalytic system. On the other hand, a copper/air catalyst enables the coupling of polyfluoroarenes with terminal alkynes. These catalyses provide new accesses to arylacetylenes through the formal direct Sonogashira coupling.