1222075-02-6Relevant articles and documents
Preparation method of canagliflozin
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, (2020/02/14)
The invention discloses a preparation method of canagliflozin. According to the method, the reaction of each step in a route is improved, so that the conversion rate of raw materials is increased, andintroduction of potential toxic compounds is avoided. In addition, reaction conditions are mild; operation is simple; purity of an obtained product is high; quality of drugs is improved; and the preparation method is suitable for industrial production.
Canagliflozin single crystal, method for preparing same and application of canagliflozin single crystal
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, (2017/04/29)
The invention relates to a canagliflozin single crystal, a method for preparing the same and application of the canagliflozin single crystal. X-ray powder of the canagliflozin single crystal has characteristic peaks when the X-ray powder is diffracted at diffraction angles 2 theta of 7.95 degrees, 10.92 degrees, 13.94 degrees, 15.46 degrees, 15.94 degrees, 18.82 degrees, 20.27 degrees, 22.72 degrees and 26.78 degrees, the obtained single crystal is not reported, crystal structures of the canagliflozin single crystal are orthorhombic systems as shown by means of measurement, space groups are P2(1)2(1)2(1), and the numbers Z of molecules in crystal packs are 4. The canagliflozin single crystal, the method and the application have the advantages that the canagliflozin single crystal is a colorless needle crystal at the normal temperature and is excellent in morphology, and the purity of the canagliflozin single crystal can reach 99%; canagliflozin can be effectively separated from other impurities by the aid of the method, and the method is good in repeatability.
card Geleg net bulk drug and preparation (by machine translation)
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, (2017/05/27)
The invention relates to a net card Geleg bulk drug and preparation, the preparation method of states card Geleg net raw material comprises a compound 1 With TMSCI, N - methyl morpholine reaction to produce compound CAN - C Compound CAN - A With a compound CAN - C, MeOH reaction to produce the compound E Compound E, acetic anhydride, N - methyl morpholine and DMAP mixing, reaction to produce the compound F Add triethyl silane, boron trifluoride ether, acetonitrile and water mixing, reaction to produce compound CAN - G Namely card Geleg net bulk drug. The preparation comprises the following weight percentage of each component: card Geleg net bulk drug, microcrystalline cellulose, anhydrous lactose, or microcrystalline cellulose aqueous solution, sodium carboxy methyl cellulose, magnesium stearate. The card gliclazide net of the raw material preparation method has high reaction yield, reagent is easy to get the advantages of the raw materials, greatly reduces the production cost of the card Geleg net raw material. (by machine translation)
TABLETS CONTAINING A 1-(?-D-GLUCOPYRANOSYL)-3-(PHENYLTHIENYLMETHYL)BENZENE COMPOUND
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Paragraph 0101, (2016/09/12)
The present invention is directed to a tablet containing a 1-(β-D-glucopyranosyl)-3-(phenylthienylmethyl)benzene compound in high drug loading, in particular, containing the compound ranging from 30 to 95% by weight of tablet and pharmaceutically acceptable additives.