1030825-21-8

Basic information

• Product Name: D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-
• Synonyms: (3R,4S,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol;(3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol;D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-;Methyl 1-C-(3-{[5-(4-fluorophenyl)-2-thienyl]Methyl}-4-Methylphenyl)-D-glucopyranoside;Canagliflozin Intermediate4;Canagliflozin Intermediates
• CAS NO: 1030825-21-8
• Molecular Formula: C₂₅H₂₇FO₆S
• Molecular Weight: 474.5416832
• Mol File: 1030825-21-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 644.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.73±0.70(Predicted)
• CAS DataBase Reference: D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-(1030825-21-8)
• EPA Substance Registry System: D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-(1030825-21-8)

Safety Data

• Hazardous Substances Data: 1030825-21-8(Hazardous Substances Data)

Usage

General Description

Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-D-Glucopyranoside is a complex chemical compound that consists of a methyl group attached to a glucose molecule and a unique arrangement of aromatic rings. The molecule also contains a thienyl group and a fluorophenyl group. D-Glucopyranoside, Methyl 1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]- has potential applications in the field of pharmaceuticals and may have biological activities due to its complex structure. However, further research is required to fully understand its potential uses and effects.

Upstream product

• 67-56-1 methanol 
• 898566-17-1 (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) 
• 32469-28-6 (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 
• 75-75-2 methanesulfonic acid 
• 1030825-20-7 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide 
• 90-80-2 D-Glucono-1,5-lactone 
• 1132832-75-7 (5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone 
• 58861-48-6 2-(4-fluorophenyl)thiophene 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 928672-86-0 (1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hemihydrate 
• 842133-18-0 canagliflozin 
• 866607-35-4 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1222075-02-6 methyl 2,3,4,6-tetra-O-acetyl-1-C-(3-{[5-(4-fluoro-phenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucopyranoside 

Relevant articles and documents

Preparation method of canagliflozin

The invention discloses a preparation method of canagliflozin. According to the method, the reaction of each step in a route is improved, so that the conversion rate of raw materials is increased, andintroduction of potential toxic compounds is avoided. In addition, reaction conditions are mild; operation is simple; purity of an obtained product is high; quality of drugs is improved; and the preparation method is suitable for industrial production.

Method for preparing Canagliflozin intermediate

The invention relates to a method for preparing a Canagliflozin intermediate. The preparation method comprises the following steps: 1) in an inert environment, at a temperature of -30 DEG C to -15 DEGC, a thiophene compound and an alkaline reagent and 2, 3, 4, 6-tetra-O-(trimethylsilane)-D-Gluconolactone are fully reacted; and 2) a methanol solution containing strong acid is added dropwise to thereaction liquid obtained in the step 1), and after full reacting, quenching and purifying are carried out to obtain the Canagliflozin intermediate. The product of the preparation method has good yield and high purity; the method has low temperature requirement for equipment, safer operation and small equipment volume requirement, and the method is more suitable for industrial scale production.

Card geleg net intermediate and its amorphous preparation method

The invention provides an Invokana intermediate and a preparation method thereof in an amorphous form. The preparation method comprises the following steps: heating and clearly dissolving (1S)-1,5-dehydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl] methyl]-4- methylphenyl-D-glucitol in a benign solvent, then dropwise adding into a rapidly-stirred poor solvent, filtering a precipitated solid and obtaining the amorphous Invokana intermediate. According to the preparation method provided by the invention, the solvent dosage can be reduced, and an obtained product is easily separated; moreover, the obtained product has good yield and high purity, and the operation is simple.