1269293-48-2

Basic information

• Product Name: ethyl 5-broMo-1-Methyl-1H-pyrazole-3-carboxylate
• Synonyms: ethyl 5-broMo-1-Methyl-1H-pyrazole-3-carboxylate;Ethyl 5-Bromo-1-methylpyrazole-3-carboxylate
• CAS NO: 1269293-48-2
• Molecular Formula: C₇H₉BrN₂O₂
• Molecular Weight: 233.06256
• Mol File: 1269293-48-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 294.216 °C at 760 mmHg
• Flash Point: 131.737 °C
• Appearance: /
• Density: 1.588 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.28±0.10(Predicted)
• CAS DataBase Reference: ethyl 5-broMo-1-Methyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-broMo-1-Methyl-1H-pyrazole-3-carboxylate(1269293-48-2)
• EPA Substance Registry System: ethyl 5-broMo-1-Methyl-1H-pyrazole-3-carboxylate(1269293-48-2)

Safety Data

• Hazardous Substances Data: 1269293-48-2(Hazardous Substances Data)

Usage

General Description

Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate is a chemical compound with the molecular formula C7H8BrN3O2. It is a derivative of pyrazole, containing a bromine atom, a methyl group, and an ester functional group. Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate is commonly used in the field of pharmaceuticals and agrochemicals, where it serves as an important intermediate for the synthesis of various biologically active compounds. Its applications include the development of antifungal and antibacterial agents, as well as potential use as a herbicide or insecticide. Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate has potential uses in medical and agricultural research and has garnered interest for its diverse chemical properties and potential for biological activity.

InChI:InChI=1S/C7H9BrN2O2/c1-3-12-7(11)5-4-6(8)10(2)9-5/h4H,3H2,1-2H3

Upstream product

• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 51986-17-5 ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate 

Downstream Products

• 1222174-93-7 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

Synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine

The invention discloses a synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine. The method comprises the steps of condensing diethyl butynedioate serving as a raw material with methylhydrazine to obtain 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester, and reacting the 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester with phosphorus oxybromide to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; hydrolyzing in a sodium hydroxide alcohol solution to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid, reacting the 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid with dimethyl azide phosphate and tert-butyl alcohol to obtain tert-butyl (5-bromine-1-methyl-1H-pyrazole-3-yl) carbamate, and hydrolyzing in trifluoroacetic acid to obtain the5-bromine-1-methyl-1H-pyrazole-3-amine. The method has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenient operation and post-treatment, and no use of highly toxic reagents, and overcomes the defects of expensive and unavailable raw materials, unsafe operation, difficult amplification and the like in the existing synthesis process.