1447607-89-7

Basic information

• Product Name: tert-butyl 5-broMo-1-Methyl-1H-pyrazol-3-ylcarbaMate
• Synonyms: tert-butyl 5-broMo-1-Methyl-1H-pyrazol-3-ylcarbaMate
• CAS NO: 1447607-89-7
• Molecular Formula: C9H14BrN3O2
• Molecular Weight: 276.13036
• Mol File: 1447607-89-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 5-broMo-1-Methyl-1H-pyrazol-3-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5-broMo-1-Methyl-1H-pyrazol-3-ylcarbaMate(1447607-89-7)
• EPA Substance Registry System: tert-butyl 5-broMo-1-Methyl-1H-pyrazol-3-ylcarbaMate(1447607-89-7)

Safety Data

• Hazardous Substances Data: 1447607-89-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
Tert-butyl 5-bromo-1-methyl-1H-pyrazol-3-ylcarbamate is used as a research chemical for the synthesis and study of various chemical compounds. Its unique structure allows for the exploration of its reactivity and potential interactions with other molecules.
Used in Drug Development:
In the pharmaceutical industry, tert-butyl 5-bromo-1-methyl-1H-pyrazol-3-ylcarbamate is used as a key intermediate in the development of new drugs. Its structure can be modified to create novel compounds with potential therapeutic effects.
Used in Medicinal Chemistry:
Tert-butyl 5-bromo-1-methyl-1H-pyrazol-3-ylcarbamate is employed in medicinal chemistry as a building block for the design of new pharmaceutical agents. Its potential biological activity makes it a promising candidate for further investigation into its therapeutic applications.
Note: Since the provided materials do not specify the exact applications or industries where tert-butyl 5-bromo-1-methyl-1H-pyrazol-3-ylcarbamate is used, the uses listed above are general and based on the information given. Further research and data are required to identify specific applications and industries.

Upstream product

• 1222174-93-7 5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 75-65-0 tert-butyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 89088-55-1 5-bromo-1-methyl-1H-pyrazol-3-amine 

Downstream Products

• 89088-55-1 5-bromo-1-methyl-1H-pyrazol-3-amine 

Relevant articles and documents

Synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine

The invention discloses a synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine. The method comprises the steps of condensing diethyl butynedioate serving as a raw material with methylhydrazine to obtain 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester, and reacting the 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester with phosphorus oxybromide to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; hydrolyzing in a sodium hydroxide alcohol solution to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid, reacting the 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid with dimethyl azide phosphate and tert-butyl alcohol to obtain tert-butyl (5-bromine-1-methyl-1H-pyrazole-3-yl) carbamate, and hydrolyzing in trifluoroacetic acid to obtain the5-bromine-1-methyl-1H-pyrazole-3-amine. The method has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenient operation and post-treatment, and no use of highly toxic reagents, and overcomes the defects of expensive and unavailable raw materials, unsafe operation, difficult amplification and the like in the existing synthesis process.

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.