122271-49-2

Upstream product

• 22028-15-5 2,3-Dimethoxy-5-(hydroxymethyl)-2,5-cyclohexadiene-1,4-dione 
• 100-39-0 benzyl bromide 
• 97315-19-0 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol 
• 97315-20-3 3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl bromide 
• 111394-55-9 3-<(tert-butyldimethylsilyl)oxy>-4,5-dimethoxybenzyl alcohol 
• 122271-48-1 2-<<(tert-butyldimethylsilyl)oxy>methyl>-5,6-dimethoxy-1,4-benzoquinone 
• 122271-45-8 3,4-dimethoxy-2,5-bis(benzyloxy)benzyl alcohol 
• 122271-44-7 3,4-dimethoxy-2,5-bis(benzyloxy)benzyl tert-butyldimethylsilyl ether 
• 122271-46-9 3-hydroxy-4,5-dimethoxybenzyl alcohol 
• 89635-21-2 3,4-dimethoxy-2,5-bis(benzyloxy)benzaldehyde 
• 121042-94-2 <3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl>triphenylphosphonium bromide 

Relevant academic research and scientific papers

Isolation, Structure, and Synthesis of Combretastatin C-1

A new cell growth inhibitory (PS ED50 2.2 μg/mL) phenanthraquinone designated combretastatin C-1 (2) has been isolated from the African tree Combretum caffrum.The structure (2) assigned combretastatin C-1 was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses.Synthetic routes 5b -> 6b -> 2 and especially 5c -> 6c -> 2 proved to be quite practical.