122307-44-2

Basic information

• Product Name: 2-(bromomethyl)-3-fluoropyridine
• Synonyms: 2-(bromomethyl)-3-fluoropyridine;2-(broMoMethyl)-3-fluorop...;2-(broMoMethyl)-3-fluoropyridine hydrochloride
• CAS NO: 122307-44-2
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.01300
• Mol File: 122307-44-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(bromomethyl)-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-3-fluoropyridine(122307-44-2)
• EPA Substance Registry System: 2-(bromomethyl)-3-fluoropyridine(122307-44-2)

Safety Data

• Hazardous Substances Data: 122307-44-2(Hazardous Substances Data)

Usage

General Description

2-(bromomethyl)-3-fluoropyridine, also known by its chemical formula C6H5BrFN, is a compound with a molecular weight of 188.015 g/mol. It is a pyridine derivative, containing a fluorine atom at the 3-position and a bromomethyl group at the 2-position. 2-(bromomethyl)-3-fluoropyridine is mainly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has been utilized in the development of fungicides, herbicides, and other crop protection products. Additionally, it has potential applications in medicinal chemistry, particularly in the synthesis of biologically active molecules. Due to its reactivity and potential for biological activity, proper handling and safety precautions are necessary when working with 2-(bromomethyl)-3-fluoropyridine in laboratory settings.

Upstream product

• 869108-35-0 methyl 3-fluoropyridine-2-carboxylate 
• 152126-31-3 3-fluoro(pyridin-2-yl)carboxylic acid 
• 372-47-4 3-Fluoropyridine 
• 31181-79-0 (3-fluoropyridin-2-yl)methanol 

Relevant articles and documents

The discovery of potent small molecule cyclic urea activators of STING

STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.

3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicyclic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.