152126-31-3

Basic information

• Product Name: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID;3-FLUOROPICOLINIC ACID;3-Fluoropyridine-2-carboxylicacid98%;2-Pyridinecarboxylicacid,3-fluoro-(9CI);3-fluropyridine-2-carboxylic acid;3-FLUOROPICOLINIC ACID / 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID;3-FLUOROPYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;3-Fluoro-2-pyridinecarboxylic acid
• CAS NO: 152126-31-3
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.1
• Product Categories: CARBOXYLICACID;PYRIDINE;Building Blocks;Carboxy;Pyridines
• Mol File: 152126-31-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 154°C
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 114.2 °C
• Appearance: /
• Density: 1.419 g/cm³
• Vapor Pressure: 0.00465mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: Room temperature.
• PKA: 2.71±0.10(Predicted)
• CAS DataBase Reference: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(152126-31-3)
• EPA Substance Registry System: 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID(152126-31-3)

Safety Data

• Hazard Codes: Xi,Xn
• HazardClass: IRRITANT
• Hazardous Substances Data: 152126-31-3(Hazardous Substances Data)

Usage

General Description

3-Fluoropyridine-2-Carboxylic Acid is a fluorinated pyridine derivative. It is often used in scientific research, particularly in the field of organic chemistry, as a building block for the synthesis of more complex compounds. This chemical compound has unique properties due to the presence of a fluorine atom and carboxylic acid group. Its structure comprises a pyridine ring, a type of aromatic heterocyclic compound, with a fluorine atom attached at the 3-position and a carboxylic acid group at the 2-position. It is generally available as a light yellow to brown crystalline powder and has the molecular formula of C6H4FNO2.

InChI:InChI=1/C6H4FNO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)

Upstream product

• 372-47-4 3-Fluoropyridine 
• 124-38-9 carbon dioxide 
• 141-78-6 ethyl acetate 
• 860296-21-5 4-chloro-3-fluoropyridine-2-carboxylic acid 
• 2546-56-7 4-chloro-3-fluoro-pyridine 

Downstream Products

• 869108-35-0 methyl 3-fluoropyridine-2-carboxylate 
• 31181-79-0 (3-fluoropyridin-2-yl)methanol 
• 122307-44-2 2-(bromomethyl)-3-fluoropyridine 
• 929569-15-3 (3-fluoropyridin-2-yl)-[5-hydroxy-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]methanone 
• 929569-02-8 1-(4-methoxybenzyl)pyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 929569-00-6 3-methyl-1-phenylpyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 929569-01-7 1-phenylpyrazolo[4',3':5,6]pyrano[3,2-b]pyridin-4(1H)-one 
• 1617540-20-1 4-oxo-1-((3'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid 
• 1617540-22-3 ethyl 4-oxo-1-((3'-(trifluoromethyl)biphenyl-2-yl)methyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylate 

Relevant articles and documents

The discovery of potent small molecule cyclic urea activators of STING

STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.

SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS

The invention relates to specific carboxamides of formula (I) as KCNQ2/3 modulators, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.

Reactivity of 1-(des-3-hydroxy-picolinoyl) pristinamycin I(A)

1-(Des-3-hydroxy-picolinoyl) pristinamycin I(A) (PI-NH2) was shown to undergo a variety of reactions, including two unexpected transformations, to afford new pristinamycin I(A) derivatives.