122329-01-5Relevant articles and documents
The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability
Gandhi, Disha M.,Rosas, Ricardo,Greve, Eric,Kentala, Kaitlin,D.-R. Diby, N'Guessan,Snyder, Vladyslava A.,Stephans, Allison,Yeung, Teresa H.W.,Subramaniam, Saravanan,DiMilo, Elliot,Kurtenbach, Khia E.,Arnold, Leggy A.,Weiler, Hartmut,Dockendorff
supporting information, p. 3788 - 3796 (2019/07/17)
Novel analogs of the allosteric, biased PAR1 ligand ML161 (parmodulin 2, PM2) were prepared in order to identify potential anti-thrombotic and anti-inflammatory compounds of the parmodulin class with improved properties. Investigations of structure-activi
[Cp?RhCl2]2-catalyzed alkyne hydroamination to 1,2-dihydroquinolines
Kumaran, Elumalai,Leong, Weng Kee
, p. 1779 - 1782 (2015/05/20)
[Cp?RhCl2]2 catalyzes the formation of 1,2-dihydroquinolines from the reaction of two terminal alkynes and an aniline. This reaction is believed to proceed via an alkyne hydroamination followed by an alkyne insertion.
Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines
Kelley,Linn,Selway
, p. 1360 - 1363 (2007/10/02)
A series of 6-anilino-9-benzyl-2-chloropurines was synthesized and tested for antirhinovirus activity. Most of the compounds were prepared by reaction of the appropriate aniline with 9-benzyl-2,6-dichloro-9H-purine. Structure-activity relationship studies
