1223446-35-2Relevant academic research and scientific papers
Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination
He, Gang,Lu, Chengxi,Zhao, Yingsheng,Nack, William A.,Chen, Gong
, p. 2944 - 2947 (2012)
An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp2)-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.
Oxalyl amide assisted palladium-catalyzed arylation of C(sp2)-H bond at the δ position
Han, Jian,Liu, Pei,Wang, Chao,Wang, Qian,Zhang, Jingyu,Zhao, Yanwei,Shi, Daqing,Huang, Zhibin,Zhao, Yingsheng
supporting information, p. 5682 - 5685 (2015/02/19)
A successful protocol has been developed for δ-arylation of β-arylethamines at the ortho position under mild conditions. The newly developed methodology first presents broad substrate scope, great functional group tolerance, and good to excellent yield in the synthesis of substituted β-arylethylamines. The transformation represents a practical advantage of oxalyl amide in assistance with C-H functionalization at a remote position.
