Archiv der Pharmazie p. 165 - 171 (1989)
Update date:2022-07-30
Topics:
Buschauer, Armin
Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.
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Doi:10.1002/ardp.19582910905
(1958)Doi:10.1055/s-0039-1690242
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(2010)Doi:10.3987/COM-09-S(S)79
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