122383-34-0

Basic information

• Product Name: (3S-CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE
• Synonyms: (3S-CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE;(3S-cis)-(-)-3-Phenyltetrahydropyrrolo-[2,1-b]oxazol-5(6H)-one,97%
• CAS NO: 122383-34-0
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 122383-34-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 76-80 °C
• Boiling Point: 341.55°C (rough estimate)
• Flash Point: 185.6°C
• Appearance: /
• Density: 1.1255 (rough estimate)
• Vapor Pressure: 4.47E-06mmHg at 25°C
• Refractive Index: 1.5260 (estimate)
• CAS DataBase Reference: (3S-CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (3S-CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE(122383-34-0)
• EPA Substance Registry System: (3S-CIS)-(-)-3-PHENYLTETRAHYDROPYRROLO-[2,1-B]-OXAZOL-5(6H)-ONE(122383-34-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• Hazardous Substances Data: 122383-34-0(Hazardous Substances Data)

Usage

Chemical Properties

off-white to light brown crystalline powder

InChI:InChI=1/C12H13NO2/c14-11-6-7-12-13(11)10(8-15-12)9-4-2-1-3-5-9/h1-5,10,12H,6-8H2/t10-,12-/m1/s1

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 1311275-81-6 (S)-N-allyl-N-(2-hydroxy-1-phenylethyl)acrylamide 
• 1311275-91-8 (S)-N-allyl-N-(2-(tert-butyldimethylsilyloxy)-1-phenylethyl)acrylamide 
• 1311275-90-7 (S)-N-(2-(tert-butyldimethylsilyloxy)-1-phenylethyl)prop-2-en-1-amine 
• 122383-29-3 (S)-(+)-N-(1-phenyl-2-hydroxyethyl)succinimide 
• 56613-80-0 D-2-phenylglycinol 
• 122383-40-8 5-Ethoxy-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 64-17-5 ethanol 

Downstream Products

• 145548-97-6 (3S,6S,7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-oxo-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-6-carboxylic acid benzyl ester 
• 1026734-17-7 (3S,6S,7R,7aR)-7-Benzo[1,3]dioxol-5-yl-5-oxo-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole-6-carboxylic acid benzyl ester 
• 145549-01-5 (3S,6S,7R,7aR)-5-Oxo-3,7-diphenyl-hexahydro-pyrrolo[2,1-b]oxazole-6-carboxylic acid benzyl ester 
• 145548-98-7 (3S,7R,7aR)-7-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 145548-90-9 (3S,7aR)-5-Oxo-3-phenyl-2,3,5,7a-tetrahydro-pyrrolo[2,1-b]oxazole-6-carboxylic acid benzyl ester 
• 145549-10-6 (S)-2-((R)-3-Benzo[1,3]dioxol-5-yl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 145549-04-8 (3S,7R,7aR)-7-Benzo[1,3]dioxol-5-yl-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 145549-06-0 (R)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-4-phenyl-pyrrolidin-2-one 
• 145549-03-7 (3S,7R,7aR)-3,7-Diphenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 145549-09-3 (S)-2-Phenyl-2-((R)-3-phenyl-pyrrolidin-1-yl)-ethanol 

Relevant articles and documents

Synthesis of heterocycles through a ruthenium-catalyzed tandem ring-closing metathesis/isomerization/N-acyliminium cyclization sequence

Tandem bicycle: In the title reaction double bonds created during ring-closing metathesis isomerize to generate reactive iminium intermediates that undergo intramolecular cyclization reactions with tethered heteroatom and carbon nucleophiles. In this way, a series of biologically interesting heterocyclic compounds can be made, including a known precursor for the total synthesis of the antiparasitic natural product harmicine. Copyright