1224442-81-2

Basic information

• Product Name: (S)-4-(4-fluorophenyl)-1-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester
• CAS NO: 1224442-81-2
• Molecular Weight: 263.268
• Mol File: 1224442-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-(4-fluorophenyl)-1-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(4-fluorophenyl)-1-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester(1224442-81-2)
• EPA Substance Registry System: (S)-4-(4-fluorophenyl)-1-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylic acid methyl ester(1224442-81-2)

Safety Data

• Hazardous Substances Data: 1224442-81-2(Hazardous Substances Data)

Upstream product

• 1224442-80-1 (R)-3-(4-fluorophenyl)-2-formylpentanedioic acid 1-methyl ester 
• 74-89-5 methylamine 
• 4926-12-9 4-(4-fluorophenyl)dihydropyran-2,6(3H)-dione 
• 3449-63-6 3-(4-fluorophenyl)pentan-1,5-dioic acid 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Pilot-plant preparation of 3,4-dihydropyridin-2-one derivatives, the core structures ofP2X7 receptor antagonists

The pilot-plant syntheses of 3 and 4, the core structures of a series of P2X7 antagonists are described. The sole stereogenic center in the dihydropyridinone ring was generated by catalytic desymmetrization. Selective formylation, followed by a tandem imination/lactamization sequence, produced the 3,4-dihydropyridin-2-one ring. The compounds 3 and 4 were produced at multikilogram scale in good overall yield (～22% over six steps) and excellent stereochemical purity (97% ee for 3, 100% ee for 4).