122452-59-9

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 16932-45-9 1-bromo-2,6-dimethoxybenzene 
• 63638-85-7 3-bromo-2-hydroxy-4-methoxybenzaldehyde 
• 74-88-4 methyl iodide 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 1432610-73-5 2-amino-5-(5-bromo-4,6-dimethoxyphenyl)-1,3,4-oxadiazole 
• 39503-50-9 2,4-dimethoxy-3-bromobenzoic acid 
• 128266-48-8 3-Bromo-2,4-dimethoxy-2',3',5'-trimethylstilben (Z) 
• 128266-47-7 3-Bromo-2,4-dimethoxy-2',3',5'-trimethylstilben (E) 
• 128266-47-7 2-Bromo-1,3-dimethoxy-4-<(E/Z)-2-(2,3,5-trimethylphenyl)-ethenyl>benzol 

Relevant academic research and scientific papers

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

ANTIBACTERIAL AGENT

An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 re

4. Synthese von Plectranthonen, diterpenoiden Phenanthren-1,4-chinonen

The following phenanthrene-1,4-diones have been synthesized by using the photocyclization of the corresponding highly substituted stilbenes as the key step: 3-hydroxy-5,7,8-trimethyl-2-(prop-2-enyl)phenanthrene-1,4-dione (1), (RS)-, (R)-, and (S)-2--1-methylethyl)acetate (2, 31, and 32, resp.), 3-hydroxy-7,8-dimethyl-2-(prop-2-enyl)phenanthrene-1,4-dione (3), 3-hydroxy-7,8,10-trimethyl-2-(prop-2-enyl)phenanthrene-1,4-dione (4), 5,7,8-trimethyl-2-(prop-2-enyl)phenanthrene-1,4-dione (17) and 3-hydroxy-2-methylphenanthrene-1,4-dione (42).The quinones 1 and 3 proved to be identical with recently isolated plectranthons A and C.Compounds 2, 31, and 32 exhibited the same UV/VIS, IR, 1H-NMR and mass spectra as natural plectranthon B, but had different melting points.This might be due either to crystal modifications or to diastereoisomerism caused by the helical structure of the phenanthrene-1,4-dione skeleton.The spectral data of synthetic 4 were not compatible with those of natural plectranthon D for which structure 4 had been proposed based mainly on 1H-NMR arguments concerning the chemical shifts of H-C(9) and H-C(10) in 1-3.Extensive 1H-NMR investigations have now revealed that the currently stated assignments of the H-C(9)/H-C(10) AB system have to be reversed for highly substituted phenanthrene-1,4-diones: in the model compounds 2-methylphenanthrene-1,4-dione (41) and 2, H-C(10) resonates at lower field as expected (peri-position), whereas in the highly substituted congeners 1, 2, 3, 31, and 32, H-C(9) is shifted paramagnetically, a fact which had lead to the erroneous assignment of structure 4 for natural plectranthon D.

SYNTHESIS OF N-SUCCINIMIDYL-2,4-DIMETHOXY-3-(TRI-N-BUTYLSTANNYL) BENZOATE VIA REGIO-SPECIFICALLY GENERATED LITHIUM 2,4-DIMETHOXY-3-LITHIOBENZOATE

Lithium 2,4-dimethoxy-3-lithiobenzoate can be efficiently generated from 2,4-dimethoxy-3-bromobenzoic acid in THF at -100 deg C.