122454-68-6Relevant articles and documents
A novel and efficient synthesis of a tetra-substituted imidazole
Hayes,Hayes, Jerome F.,Mitchell,Mitchell, Michael B.,Procter,Procter, Carry
, p. 273 - 274 (1994)
A novel synthesis of a tetra-substituted imidazole is described. A key feature of the synthesis is the regioselective deprotonation of picolylpyrrolidinone 3 and the efficient reaction of this anion with an aryl nitrile to give the pyrrolidinoimidazole nu
Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
-
, (2008/06/13)
A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fuse