1224639-71-7

Basic information

• Product Name: [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone
• Synonyms: [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone
• CAS NO: 1224639-71-7
• Molecular Weight: 519.225
• Mol File: 1224639-71-7.mol

Chemical Properties

• CAS DataBase Reference: [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone(1224639-71-7)
• EPA Substance Registry System: [2-(4-bromo-2,5-dichloro-phenoxy)-pyridin-3-yl]-(4-cyclopropyl-3,4-dihydro-2Hquinoxalin-1-yl)-methanone(1224639-71-7)

Safety Data

• Hazardous Substances Data: 1224639-71-7(Hazardous Substances Data)

Upstream product

• 1940-42-7 4-bromo-2,5-dichlorophenol 
• 2942-59-8 2-chloronicotinic acid 
• 1224640-12-3 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-11-2 1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-10-1 N-cyclopropyl-N-(2-nitro-phenyl)-oxalamic acid methyl ester 
• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1224640-13-4 1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline 
• 1224640-17-8 2-(4-bromo-2,5-dichloro phenoxy)nicotinic acid 

Downstream Products

• 1224639-72-8 (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{2-[2,5-dichloro-4-(3-hydroxy-prop-1-ynyl)-phenoxy]-pyridin-3-yl}-methanone 
• 1432659-52-3 C₂₉H₂₃Cl₂N₅O₅S 
• 1432659-53-4 C₂₅H₂₀Cl₂N₈O₃ 
• 1224640-24-7 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-benzoic acid 
• 1224639-91-1 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-benzoic acid methyl ester 
• 1224639-75-1 2-chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid methyl ester 
• 1224640-23-6 3-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)pyridin-2-yloxy]phenyl}acrylic acid ethyl ester 

Relevant articles and documents

2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

Potency with potential: 2-Phenoxy- nicotinamides were identified as potent agonists at the GPBAR1 receptor, a target in the treatment of obesity, type2 diabetes and metabolic syndrome. Extensive structure-activity relationship studies supported by homolog

NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.