122479-53-2Relevant academic research and scientific papers
Imidazopyridazines. XVIII. Syntheses and Central Nervous System Activities of Some 6-, 7- and 8-(Chloro and methoxy)imidazopyridine Analogues
Barlin, Gordon B.,Davies, Les P.,Harrison, Peter W.
, p. 1031 - 1038 (2007/10/02)
Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy)-6(7 and 8)-chloro- and 6(and 8)-methoxy-imidazopyridines.In tests of the ability of these compounds to displace diazepam from rat brain membrane, those with 6-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazopyridines and imidazopyridazines.
Imidazopyridazines. VII. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-benzyloxy(and methoxybenzyloxy)-2-phenyl(substituted phenyl or pyridinyl)imidazopyridazines
Barlin, Gordon B.,Davies, Les P.,Ngu, Maria M. L.
, p. 1749 - 1757 (2007/10/02)
A series of 15 3-alkoxy-6-benzyloxy(methoxybenzyloxy)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines has been prepared and each compound tested for its ability to displace 3H-diazepam from rat brain plasma membranes.The results have b
