122485-48-7

Upstream product

• 122428-60-8 α-benzyloxyiminoacetophenone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 98-86-2 acetophenone 
• 122428-61-9 α-acetoxyacetophenone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 122428-62-0 α-hydroxyacetophenone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 122428-63-1 (4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolane-2-carbaldehyde 
• 51064-64-3 (S,S)-(-)-4,5-Bis(methoxymethyl)-2,2-dimethyl-1,3-dioxolan 
• 28203-05-6 dimethoxy-2,2 phenyl-2 ethanol-1 
• 50622-10-1 (-)-(2S,3S)-1,4-dimethoxy-2,3-butanediol 

Downstream Products

• 122428-66-4 2S-2-acetamido-1-phenyl-1-propanone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 
• 57760-14-2 (S)-(-)-N-acetyl-α-methylphenylethylamine 
• 122428-65-3 2S-2-amino-1-phenyl-1-propanone (2S,3S)-1,4-dimethoxy-2,3-butylene acetal 

Relevant academic research and scientific papers

Asymmetric Synthesis Using Chiral Acetals: Highly Diastereoselective Addition of Organocerium Reagents to Chiral α-Aldoxime-Ether Acetal

Nucleophilic addition of organometallic reagents to the chiral α-aldoxime-ether acetal (1) was studied.Among the reagents, organocerium reagents showed higher reactivity and stereoselectivity, giving the N-oxygenated chiral amine derivatives (6Aa-c) in a highly diastereoselective manner, whereas Grignard and organolithium reagents afforded no 6.As an application of the reaction, the synthesis of (-)-N-acetylamphetamine (11) was achieved.