28203-05-6

Basic information

• Product Name: 2,2-DIMETHOXY-2-PHENYL-ETHANOL
• Synonyms: 2,2-DIMETHOXY-2-PHENYL-ETHANOL;2-Phenyl-2,2-dimethoxyethanol
• CAS NO: 28203-05-6
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.21636
• Mol File: 28203-05-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 277.8°Cat760mmHg
• Flash Point: 121.8°C
• Appearance: /
• Density: 1.095g/cm³
• Vapor Pressure: 0.00212mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 2,2-DIMETHOXY-2-PHENYL-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHOXY-2-PHENYL-ETHANOL(28203-05-6)
• EPA Substance Registry System: 2,2-DIMETHOXY-2-PHENYL-ETHANOL(28203-05-6)

Safety Data

• Hazardous Substances Data: 28203-05-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 691, 1984 DOI: 10.1016/S0040-4039(01)80001-0

InChI:InChI=1/C10H14O3/c1-12-10(8-11,13-2)9-6-4-3-5-7-9/h3-7,11H,8H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 4747-13-1 α-methoxystyrene 
• 98-86-2 acetophenone 
• 124-41-4 sodium methylate 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 124513-23-1 2,2-dimethoxyphenethyl (tert-butyldimethylsilyl)acetate 
• 19159-39-8 phenylglyoxal dimethylacetal 
• 5650-40-8 2-hydroxypropiophenone 
• 1231-51-2 2,5-dimethoxy-2,5-diphenyl-1,4-dioxane 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 69626-31-9 2-[(prop-2-yn-1-yl)oxy]-1-phenylethan-1-one 
• 73566-21-9 1-phenyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethan-1-one 

Relevant articles and documents

Precatalyst-Enabled Selectivity: Enantioselective NiH-Catalyzed anti-Hydrometalative Cyclization of Alkynones to Endo- and Heterocyclic Allylic Alcohols

A highly enantioselective NiH-catalyzed hydrocyclization of alkynones with unparalleled anti- and endocyclic selectivities is described. The choice of the precatalysts has significant influence in tuning the regio- and enantioselectivity. Using Ni(OTs)su

Distal Functional Group Migration for Visible-light Induced Carbo-difluoroalkylation/monofluoroalkylation of Unactivated Alkenes

A general and practical protocol for elusive carbo-difluoroalkylation/ monofluoroalkylation of unactivated alkenes based on the distal functional group migration is described. A portfolio of functional groups including heteroaryl, imino, formyl, and alkynyl groups showcase the migratory aptitude. In combination with visible-light photocatalysis, a broad range of di- and mono-fluorinated alkyl ketones are readily obtained in synthetically useful yields under mild reaction conditions. (Figure presented.).

Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides

Novel α-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. α-Bromination yielded α-bromo-α-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5′-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks.