1224955-46-7Relevant academic research and scientific papers
Pt(IV)-catalyzed hydroamination triggered cyclization: A strategy to fused pyrrolo[1,2- a ]quinoxalines, Indolo[1,2- a ]quinoxalines, and Indolo[3,2- c ]quinolines
Patil, Nitin T.,Kavthe, Rahul D.,Shinde, Valmik S.,Sridhar, Balasubramanian
supporting information; experimental part, p. 3371 - 3380 (2010/07/02)
A PtCl4-catalyzed hydroamination-triggered cyclization strategy to access biologically interesting N-containing heterocycles such as pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, and indolo[3,2-c] quinolines is described. The reaction makes use of aminoaromatics such as 1-(2-aminophenyl)pyrroles, N-(2-aminophenyl)indoles, 2-(2-aminophenyl)indoles, and alkynes having a tethered hydroxyl group. Mechanistically, the reaction is very appealing since it involves multiple catalytic cycles catalyzed by a single metal catalyst PtCl4. We observed a remarkable enhancement of the rate when reactions were run under microwave-assisted conditions.
