1225048-88-3

Basic information

• Product Name: 1-[3-(4-bromo-phenoxy)-2-hydroxypropyl]-2-hydroxymethyl-piperidine-3,4,5-triol
• CAS NO: 1225048-88-3
• Molecular Weight: 392.247
• Mol File: 1225048-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[3-(4-bromo-phenoxy)-2-hydroxypropyl]-2-hydroxymethyl-piperidine-3,4,5-triol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(4-bromo-phenoxy)-2-hydroxypropyl]-2-hydroxymethyl-piperidine-3,4,5-triol(1225048-88-3)
• EPA Substance Registry System: 1-[3-(4-bromo-phenoxy)-2-hydroxypropyl]-2-hydroxymethyl-piperidine-3,4,5-triol(1225048-88-3)

Safety Data

• Hazardous Substances Data: 1225048-88-3(Hazardous Substances Data)

Upstream product

• 19130-96-2 1,5-dideoxy-1,5-imino-D-glucitol 
• 2212-06-8 2-((4-bromophenoxy)methyl)oxirane 

Relevant articles and documents

Synthesis and biological activity of novel deoxynojirimycin derivatives as potent α-glucosidase inhibitors

Thirteen 1-deoxynojirimycin (DNJ) derivatives of five different skeletal structures were designed and synthesized. The newly synthesized compounds were evaluated using an in vitro α-glucosidase assay, and kinetic parameters (Ki, IC50) were measured. Some DNJ derivatives showed weak α-glucosidase inhibitory activities, and the compounds 1-(3-benzyloxy-2-hydroxypropyl)- 2-hydroxymethyl-piperidine-3,4,5-triol (2a) and 1-{3-[1-(4-fluorophenyl)-1H-[1,2,3]triazol-4-ylmethoxy]- 2-hydroxypropyl}-2- hydroxymethyl-piperidine-3,4,5-triol (13d) showed activities comparable to that of DNJ. While 2a was found to be a reversible, non-competitive inhibitor of a-glucosidase with a Ki value of 1.56×10-4 M and an IC 50 value of 3.07×10-4 M, 13d was a reversible, competitive inhibitor of α-glucosidase with a Ki value of 2.08×10-4 M and an IC50 value of 3.31×10 -4 M.