122517-80-0

Basic information

• Product Name: (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate
• Synonyms: (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate
• CAS NO: 122517-80-0
• Molecular Weight: 226.229
• Mol File: 122517-80-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate(122517-80-0)
• EPA Substance Registry System: (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate(122517-80-0)

Safety Data

• Hazardous Substances Data: 122517-80-0(Hazardous Substances Data)

Upstream product

• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 79-15-2 N-bromoacetamide 
• 832-01-9 methyl p-methoxycinnamate 
• 123-11-5 4-methoxy-benzaldehyde 
• 130718-65-9 (R)-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)-3-(trimethylsilyloxy)propan-2-one 
• 130718-74-0 (4R,5R)-cis-4--5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan 
• 130796-28-0 (4S,5R)-trans-4--5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan 
• 130718-67-1 (R)-3-hydroxy-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one 
• 130718-72-8 threo (2S,3R)-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propane-2,3-diol 
• 130718-70-6 erythro (2R,3R)-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propane-2,3-diol 
• 130718-64-8 methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate 
• 127489-32-1 (4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid 
• 130718-76-2 (4R,5R)-cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde 
• 130796-31-5 (4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde 

Downstream Products

• 127347-52-8 (2S,3R)-3-Hydroxy-3-(4-methoxy-phenyl)-2-(2,4,6-trichloro-benzenesulfonyloxy)-propionic acid methyl ester 
• 1353660-94-2 C₃₁H₄₀N₄O₈ 
• 1353660-74-8 C₄₆H₆₆N₄O₁₀ 
• 1353660-82-8 C₃₇H₄₈N₄O₇ 
• 1353660-37-3 (2S,3S)-methyl 3-azido-2-hydroxy-3-(4-methoxyphenyl)propanoate 
• 1353660-45-3 (2S,3S)-methyl 3-azido-2-methoxy-3-(4-methoxyphenyl)propanoate 
• 1353660-55-5 (2S,3S)-methyl 3-amino-2-methoxy-3-(4-methoxyphenyl)propanoate 
• 1353660-64-6 C₃₂H₄₂N₄O₈ 
• 68856-96-2 N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine 
• 94790-24-6 (2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester 
• 856899-98-4 methyl 2-dihydroxy-3-(4-methoxyphenyl)propanoate 
• 122431-48-5 methyl (4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate 
• 130796-31-5 (4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde 
• 42399-48-4 (2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propionic acid 

Relevant articles and documents

Synthesis of unit-B of cryptophycin-24 via Sharpless asymmetric dihydroxylation

A synthetic pathway for the synthesis of unit-B of cryptophycin-24 has been developed using Sharpless asymmetric dihydroxylation as the key step. This study shows that direct azidation of α-hydroxy acid ester using diphenylphosphoryl azide is beneficial to asymmetric synthesis of α-amino acid without the loss of chirality during the transformation.

Catalytic asymmetric dihydroxylation of olefins with recyclable osmate-exchanged chloroapatite catalyst

An osmate-exchanged chloroapatite (CAP-OsO4) catalyst was prepared by an ion-exchange technique. CAP-OsO4 efficiently catalyses asymmetric dihydroxylation of olefins including α,β-unsaturated esters and amides to afford the corresponding diols in high yields and enantioselectivities. The catalyst was reused for several cycles with consistent activity.

Synthesis of taxoids II. Synthesis and antitumor activity of water-soluble taxoids

Synthesis of novel taxoid water-soluble prodrugs that have 2′-substituted amino acid derivatives with spacer is described. Enantioselective synthesis of the C-13 side chains proceeded through the asymmetric dihydroxylation. Several compounds had good solubility in saline and showed potent antitumor activity against B16 melanoma in mice.