122536-72-5

Basic information

• Product Name: (S)-3-AMINO-1-CBZ-PYRROLIDINE
• Synonyms: (S)-BENZYL-3-AMINOPYRROLIDINE-1-CARBOXYLATE;(S)-1-BENZYLOXYCARBONYL-3-AMINOPYRROLIDINE;(S)-(+)-1-CBZ-3-AMINOPYRROLIDINE;(S)-3-AMINO-1-CBZ-PYRROLIDINE;(S)-3-Amino-1-N-Cbz-pyrrolidine;(S)-3-AMino-1-N-cbz-pyrrolidine HCl;(S)-(+)-3-AMino-1-(benzyloxycarbonyl)pyrrolidine, 96%;benzyl (3S)-3-aminopyrrolidine-1-carboxylate
• CAS NO: 122536-72-5
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Product Categories: pharmacetical
• Mol File: 122536-72-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 310-316℃
• Boiling Point: 315 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.155 g/mL at 25 °C
• Vapor Pressure: 4.04E-05mmHg at 25°C
• Refractive Index: n20/D 1.548
• PKA: 9.52±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: (S)-3-AMINO-1-CBZ-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINO-1-CBZ-PYRROLIDINE(122536-72-5)
• EPA Substance Registry System: (S)-3-AMINO-1-CBZ-PYRROLIDINE(122536-72-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 122536-72-5(Hazardous Substances Data)

Usage

General Description

"(S)-3-Amino-1-CBZ-Pyrrolidine is a chemical compound that falls under the category of organics and amino acids. The term "CBZ" in its name refers to the carbobenzyloxy group, a protective group for amines in organic synthesis. This suggests that the chemical compound is used in protecting amines during the synthesis process. The "S" in the name indicates the configuration of the stereogenic center of the molecule which is based on the Cahn-Ingold-Prelog priority rules. It forms part of the complex processes involved in chemical, biochemical, pharmaceutical, and medicinal research and production. Detailed information about its properties, usage, and safety measures would be necessary for handling and working with this compound.

InChI:InChI=1/C12H16N2O2/c13-11-6-7-14(8-11)12(15)16-9-10-4-2-1-3-5-10/h1-5,11H,6-9,13H2/t11-/m0/s1

Upstream product

• 122536-74-7 (S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 501-53-1 benzyl chloroformate 
• 122536-70-3 (S)-3-azido-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 122536-68-9 (R)-3-<(methylsulfonyl)oxy>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 100858-33-1 (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 

Downstream Products

• 791635-08-0 (3S)-3-cyclohexylamino-pyrrolidine-1-carboxylic acid benzyl ester 
• 859213-29-9 (S)-1-(benzyloxycarbonyl)-3-(N,N-diethylamino)pyrrolidine 
• 1438288-53-9 benzyl (R)-3-(3-(3-chlorophenethyl)-2,4,6-trioxotetrahydropyrimidin-1(2H)-yl)pyrrolidine-1-carboxylate 
• 140412-80-2 *,R^*)>-3-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-1-oxopropyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 122536-74-7 (S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-1-pyrrolidinecarboxylic acid phenylmethyl ester 

Relevant articles and documents

COMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS

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Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3- amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity

A series of amino acid prodrugs of racemic and chiral 7-(3-amino-1- pyrrolidinyl)-6-fluoro-1,8-naphthyridine-3-carboxylic acids, 1-cyclopropyl- 6,8-difluoro-3-quinolinecarboxylic acids, 1-cyclopropyl-6-fluoro-3- quinolinecarboxylic acids, and 5-amino-1-cyclopropyl-6,8-difluoro-3- quinolinecarboxylic acids have been prepared and evaluated for comparative antibacterial activity. Compounds were prepared by acylation of the 3-amino group of the pyrrolidine with common amino acids using standard peptide chemistry. This series has been compared with the parent compounds for antibacterial activity in vitro and in vivo as well as for comparative solubility. The amino acid analogues were less active in vitro, but had equal or increased efficacy in vivo. Indeed, it was proven that these compounds, which were stable to acid and base under the reaction conditions for their preparation, were rapidly cleaved in serum to give the parent quinolones. The amino acid derivatives showed a 3-70 times improved solubility when compared to the parent compounds. The most active compound of the series was [S- (R*,R*)]-7-[3-[(2-amino-1-oxopropyl)-amino]-1-pyrrolidinyl]-1-cyclopropyl- 6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (PD 131112).