1225463-76-2

Basic information

• Product Name: 2-(N-benzyl-N-methylamino)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 2-(N-benzyl-N-methylamino)-5-phenyl-1,3,4-oxadiazole
• CAS NO: 1225463-76-2
• Molecular Weight: 265.315
• Mol File: 1225463-76-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(N-benzyl-N-methylamino)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-benzyl-N-methylamino)-5-phenyl-1,3,4-oxadiazole(1225463-76-2)
• EPA Substance Registry System: 2-(N-benzyl-N-methylamino)-5-phenyl-1,3,4-oxadiazole(1225463-76-2)

Safety Data

• Hazardous Substances Data: 1225463-76-2(Hazardous Substances Data)

Upstream product

• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 3555-71-3 N-benzyl-N-chloromethylamine 
• 103-67-3 benzyl-methyl-amine 
• 613-94-5 benzoic acid hydrazide 

Relevant articles and documents

Amination of benzoxazoles and 1,3,4-oxadiazoles using 2,2,6,6- tetramethylpiperidine-N-oxoammonium tetrafluoroborate as an organic oxidant

No transition metals are necessary to convert benzoxazoles and 1,3,4-oxadiazoles into the corresponding pharmacologically interesting 2-aminated heterocycles by formal direct C(2)-amination using tetramethylpiperidine-N-oxoammonium tetrafluoroborate (TEMPO+BF 4-) as an oxidant (see scheme; TEMP=2,2,6,6- tetramethylpiperidine; TfOH=trifluoromethanesulfonic acid).

Cobalt- and manganese-catalyzed direct amination of azoles under mild reaction conditions and the mechanistic details

A bonding moment: A new cobalt- or manganese-catalyzed amination of azoles has been developed using peroxide and an acid additive to couple various types of azoles with ammonia, and primary or secondary amines (see scheme). The catalyst loadings are low, the optimal reaction conditions are mild, and the substrate scope is broad. The product azoles are an important pharmacophore of high biological activity. Copyright