122570-91-6Relevant articles and documents
2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones
Li, Kangnan,Shao, Xinxin,Tseng, Luke,Malcolmson, Steven J.
, p. 598 - 601 (2018)
We introduce a new strategy for synthesis of chiral amines: couplings of α-aminoalkyl nucleophiles generated by enantioselective migratory insertion of 2-azadienes to a Cu-H. In this report, we demonstrate its application in catalytic reductive coupling of 2-azadienes and ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.
Synthesis of an α-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase
Steere, Jennifer A.,Sampson, Peter B.,Honek, John F.
, p. 457 - 460 (2007/10/03)
A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics.
New approach to the synthesis of heterocyclic α-aminophosphonic acids
El Khalabi,El Hallaoui,Ouazzani,Elachqar,El Hajji,Atmani,Roumestant,Viallefont,Martinez
, p. 85 - 94 (2007/10/03)
Heterocyclic α-aminophosphonic acids were obtained by 1,3-dipolar cycloaddition reaction of azides with alkynes.
