1226-96-6

Upstream product

• 1222-76-0 2-phenyl-5-phenylethylfuran 
• 110598-66-8 (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal 
• 435344-70-0 methyl 2-[(tert-butyldimethylsilyl)oxy]-4-phenylbutanoate 
• 7226-82-6 (RS)-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 83402-87-3 2-oxo-4-phenylbutyric acid methyl ester 
• 16640-69-0 4-phenyl-1-(triphenylphosphoranylidene)butan-2-one 
• 163667-14-9 2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 148204-86-8 (tert-butyldimethylsilanyloxy)phenylacetic acid methyl ester 
• 4358-87-6 (RS)-methyl mandelate 
• 611-71-2 MANDELIC ACID 
• 1222465-67-9 trans-4-hydroxy-1,6-diphenylhex-2-en-1-one 
• 32257-31-1 2-((1-phenylprop-2-yn-1-yl)oxy)tetrahydro-2H-pyran 
• 2579-22-8 Phenylpropargyl aldehyde 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 

Relevant academic research and scientific papers

A method of synthesizing chiral alkene propyl alcohol

The invention discloses a method for synthesizing chiral alkene propyl alcohol method, which belongs to the technical field of organic chemistry. The method adopts the [...] derived binaphthol potassium salt as a chiral [...] catalyst, catalytic [...] pro

Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies

The development and characterization of enantioselective catalytic kinetic resolution of allylic alcohols through asymmetric isomerization with chiral BINOL derivatives-based alkoxides as bifunctional Br?nsted base catalysts were described in the study. A number of chiral BINOL derivatives-based alkoxides were synthesized, and their structure-enantioselectivity correlation study in asymmetric isomerization identified a promising chiral Br?nsted base catalyst, which afforded various chiral secondary allylic alcohols (ee up to 99%, S factor up to >200). In the mechanistic study, alkoxide species were identified as active species and the phenol group of BINOL largely affected the high reactivity and enantioselectivity via hydrogen bonding between the chiral Br?nsted base catalyst and substrates. The strategy is the first successful synthesis strategy of various chiral secondary allylic alcohols through enantioselective transition-metal-free base-catalyzed isomerization. The applicability of the strategy had been demonstrated by the synthesis of the bioactive natural product (+)-veraguensin.

2,5-Disubstituted furans from 1,4-alkynediols

1,4-Alkynediols serve as readily available starting materials for isomerisation to 1,4-diketones, which can be converted in situ into the corresponding furans by acid-catalysed dehydration. A range of 2,5-disubstituted furans was prepared using the ruthenium-based catalyst Ru(PPh3)3(CO)H2 with Xantphos at 1 mol % loading.