16640-69-0

Basic information

• Product Name: 2-Butanone, 4-phenyl-1-(triphenylphosphoranylidene)-
• CAS NO: 16640-69-0
• Molecular Formula: C28H25OP
• Molecular Weight: 408.48
• Mol File: 16640-69-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 4-phenyl-1-(triphenylphosphoranylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 4-phenyl-1-(triphenylphosphoranylidene)-(16640-69-0)
• EPA Substance Registry System: 2-Butanone, 4-phenyl-1-(triphenylphosphoranylidene)-(16640-69-0)

Safety Data

• Hazardous Substances Data: 16640-69-0(Hazardous Substances Data)

Upstream product

• 83199-89-7 tert-butyl 3-oxo-5-phenyl-2-(triphenylphosphoranylidene)pentanoate 
• 645-45-4 hydrocinnamic acid chloride 
• 38940-14-6 triphenyl-(4-phenyl-2-oxobutyl)phosphonium bromide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 603-35-0 triphenylphosphine 
• 83199-83-1 tert-butyl 3-oxo-2-(triphenylphosphoranylidene)-4-pentenoate 
• 83199-82-0 t-Butyl 5-Chloro-3-oxo-2-(triphenylphosphoranylidene)-pentanoate 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 100-39-0 benzyl bromide 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 100-44-7 benzyl chloride 
• 30911-16-1 S-ethyl 3-phenylpropionic acid thioester 
• 1031-15-8 methyltriphenylphosphonium chloride 

Downstream Products

• 17615-03-1 Triphenyl-(hydrocinnamoyl-methoxycarbonyl-methyl-methylen)-phosphoran 
• 41639-72-9 (1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one 
• 1395101-15-1 (4E,9E)-1,13-diphenyltrideca-4,9-diene-3,11-dione 
• 1429430-91-0 C₁₇H₂₀O₂ 
• 1429431-02-6 C₁₈H₂₂O₂ 
• 1429430-28-3 C₂₄H₂₆O₂ 
• 1429430-80-7 C₁₅H₁₈O₂ 
• 1098095-15-8 (6R)-6-[(2E)-4-oxo-6-phenylhex-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one 
• 1225487-37-5 (6S)-5,6-dihydro-6-[(2E)-4-oxo-6-phenylhex-2-en-1-yl]-2H-pyran-2-one 

Relevant articles and documents

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Reductive Halogenation Reactions: Selective Synthesis of Unsymmetrical α-Haloketones

A method for the selective synthesis of unsymmetrical α-haloketones has been developed. The key transformation is a triphenylphosphine oxide catalyzed reductive halogenation of an α,β-unsaturated ketone in which trichlorosilane is the reducing reagent and an N-halosuccinimide is the electrophilic halogen source. This method allows for a halogen atom to be installed selectively at either of two very similarly substituted sites adjacent to a ketone group.

Synthesis of trifluoromethyl-/cyclopropyl-substituted 2-isoxazolines by DBU-promoted domino reaction

NTrifluoromethyl and cyclopropyl substituted 2-isoxazolines were synthesized via a DBU-promoted domino reaction of β-trifluoromethyl-/β-cyclopropyl-substituted enones with hydroxylamine. The domino reaction consists of a Michael addition and the followed cyclization. A wide range of 3-substituted 5-cyclopropyl-5- trifluoromethyl-2-isoxazolines were obtained in good to excellent yields under mild reaction conditions. The method could also apply to other trifluoromethyl-substituted enones.