1226509-63-2

Upstream product

• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 423756-29-0 1,2-bis-bromomethyl-4,5-diiodo-benzene 
• 1226509-13-2 diethyl 2-acetyl-6,7-diiodo-1,2-dihydroisoquinoline-3,3-dicarboxylate 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

Diversity-oriented approach to 1,2,3,4-tetrahydroiso-quinoline-3-carboxylic acid (Tic) derivatives using diethyl acetamidomalonate as a glycine equivalent: Further expansion by Suzuki-Miyaura cross-coupling reaction

Synthesis of diverse l,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and its higher analogues are reported using diethyl acetamidomalonate as a glycine equivalent. In addition, various substituted Tic derivatives are assembled by application of SuzukiMiyaura cross-coupling reaction as a key step.

Diversity-oriented approach to 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (TIC) derivatives

A convenient method is reported for synthesizing various 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives and bis-armed-amino acid derivatives by treating dibromo-o-xylylenes precursor with diethyl acetamidomalonate under basic conditions. Suzuki coupling reaction has been used to expand this methodology. One of the structure revision of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid into bis-armed amino acid is also reported.