1226784-41-3

Basic information

• Product Name: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate
• Synonyms: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate
• CAS NO: 1226784-41-3
• Molecular Weight: 334.411
• Mol File: 1226784-41-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate(1226784-41-3)
• EPA Substance Registry System: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate(1226784-41-3)

Safety Data

• Hazardous Substances Data: 1226784-41-3(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 141-78-6 ethyl acetate 

Downstream Products

• 1274019-46-3 ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate 

Relevant articles and documents

One-pot enol silane formation-Mukaiyama aldol reactions: Crossed aldehyde-aldehyde coupling, thioester substrates, and reactions in ester solvents

Trimethylsilyl trifluoromethanesulfonate (TMSOTf) and a trialkylamine base promote both in situ enol silane/silyl ketene acetal formation and Mukaiyama aldol addition reactions between a variety of reaction partners in a single reaction flask. Isolation of the required enol silane or silyl ketene acetal is not necessary. For example, crossed aldol reactions between α-disubstituted aldehydes and non-enolizable aldehydes yield β-hydroxy aldehydes in good yield. In a related reaction, the common laboratory solvent ethyl acetate functions as both an enolate precursor and a green reaction solvent. When thioesters are employed as enolate precursors, high yields for additions to non-enolizable aldehydes are routinely observed.