ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate

Base Information

• Chemical Name: ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate
• CAS No.: 1226784-41-3
• Molecular Formula: C₁₅H₂₁F₃O₃Si
• Molecular Weight: 334.411
• Mol file: 1226784-41-3.mol

Synonyms:ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate

Chemical Property of ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate

There total 2 articles about ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + 1-ethoxy-1-(trimethylsiloxy)ethene (18295-66-4) → ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate (1226784-41-3)

Guidance literature:

In toluene; at 23 ℃; for 3h; Inert atmosphere; Molecular sieve;

DOI:10.3987/COM-09-S(S)133

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + trimethylsilyl trifluoromethanesulfonate (27607-77-8) + ethyl acetate (141-78-6) → ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate (1226784-41-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151192

Reference yield:

ethyl 3-[(4-trifluoromethyl)phenyl]-3-trimethylsiloxypropanoate (1226784-41-3) → ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate (1274019-46-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151192

upstream raw materials:

4-Trifluoromethylbenzaldehyde

1-ethoxy-1-(trimethylsiloxy)ethene

trimethylsilyl trifluoromethanesulfonate

ethyl acetate

Downstream raw materials:

ethyl 3-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoate

Refernces

• 1、 Anada, Masahiro,Washio, Takuya,Watanabe, Yudai,Hashimoto, Shunichi. "The Mukaiyama aldol and Mukaiyama-Michael reactions promoted by commercially available molecular sieves". experimental part. p. 1489 - 1503. Retrieved 2010/10/20.