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  • SAGECHEM/5-methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine/SAGECHEM/Manufacturer in China

    Cas No: 1227210-32-3

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1227210-32-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1227210-32-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,2,1 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1227210-32:
103 % 10 = 3
So 1227210-32-3 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 5-methyl-2-nitro-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine

1.2 Other means of identification

Product number -
Other names 5-methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1227210-32-3 SDS

1227210-32-3Relevant articles and documents

A concise synthesis of a tetrahydropyrazolopyrazine building block

Shu, Lianhe,Wang, Ping,Gu, Chen,Garofalo, Lisa,Alabanza, Lady Mae,Dong, Yan

, p. 1870 - 1873 (2012)

A concise synthesis of a tetrahydropyrazolopyrazine building block is described. 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamine was prepared in three steps and 80% yield from 5-nitro-2H-pyrazole-3-carboxylic acid. This compound was then coupled with 4-bromo-6-chloro-2-methyl-2H- pyridazin-3-one in the presence of sodium tert-pentoxide to give the target product in 87% yield. The process was successfully scaled up to a multihundred gram scale.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Young, Wendy B.,Barbosa, James,Blomgren, Peter,Bremer, Meire C.,Crawford, James J.,Dambach, Donna,Eigenbrot, Charles,Gallion, Steve,Johnson, Adam R.,Kropf, Jeffrey E.,Lee, Seung H.,Liu, Lichuan,Lubach, Joseph W.,MacAluso, Jen,MacIejewski, Pat,Mitchell, Scott A.,Ortwine, Daniel F.,Di Paolo, Julie,Reif, Karin,Scheerens, Heleen,Schmitt, Aaron,Wang, Xiaojing,Wong, Harvey,Xiong, Jin-Ming,Xu, Jianjun,Yu, Christine,Zhao, Zhongdong,Currie, Kevin S.

, p. 575 - 579 (2016/01/09)

BTK inhibitor GDC-0834 (1) was found to be rapidly metabolized in human studies, resulting in a suspension of clinical trials. The primary route of metabolism was through cleavage of the acyclic amide bond connecting the terminal tetrahydrobenzothiophene



, (2015/11/16)

Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X, X, and Xare N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I foranddiagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

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