1227306-89-9Relevant academic research and scientific papers
Synthesis and SAR studies of fused oxadiazines as γ-secretase modulators for treatment of Alzheimer's disease
Huang, Xianhai,Zhou, Wei,Liu, Xiaoxiang,Li, Hongmei,Sun, George,Mandal, Mihirbaran,Vicarel, Monica,Zhu, Xiaohong,Bennett, Chad,McCraken, Troy,Pissarnitski, Dmitri,Zhao, Zhiqiang,Cole, David,Gallo, Gioconda,Zhu, Zhaoning,Palani, Anandan,Aslanian, Robert,Clader, John,Czarniecki, Michael,Greenlee, William,Burnett, Duane,Cohen-Williams, Mary,Hyde, Lynn,Song, Lixin,Zhang, Lili,Chu, Inhou,Buevich, Alexei
, p. 931 - 935 (2013/01/15)
Fused oxadiazines (3) were discovered as selective and orally bioavailable γ-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure-activity relationsh
GAMMA SECRETASE MODULATORS
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Page/Page column 145, (2010/06/15)
In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions
