1227311-10-5

Basic information

• Product Name: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate
• Synonyms: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate
• CAS NO: 1227311-10-5
• Molecular Weight: 332.4
• Mol File: 1227311-10-5.mol

Chemical Properties

• Boiling Point: 491.2±45.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• CAS DataBase Reference: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate(1227311-10-5)
• EPA Substance Registry System: methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate(1227311-10-5)

Safety Data

• Hazardous Substances Data: 1227311-10-5(Hazardous Substances Data)

Upstream product

• 75344-77-3 4-bromo-3,5-dimethyl benzonitrile 
• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 80312-69-2 N-t-butoxycarbonyl-D,L-serinamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 298693-79-5 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoate 
• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 

Downstream Products

• 623950-02-7 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid 
• 623950-05-0 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoate 

Relevant articles and documents

L-alanine derivative preparation method

The invention relates to the preparation of pharmaceutical intermediates, and belongs to the field of organic synthesis, particularly to an L-alanine derivative preparation method, which comprises: carrying out a Negishi reaction on a compound 3 to obtain

OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Preparation method of alanine derivatives

The invention discloses a method for preparing alanine derivatives disclosed as Formula (I). The alanine derivatives can be used as a synthesis intermediate of an opioid receptor regulator, such as a synthesis intermediate of eluxadoline. By using the cheap and accessible chiral tyrosine as the initial raw material, the invention provides a brand-new synthesis route for preparing alanine derivatives. The whole reaction route has the advantages of high total yield, low cost and mild reaction conditions, is simple and safe for operation, and is suitable for large-scale industrial production.

PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES

The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.