298693-79-5

Basic information

• Product Name: L-Phenylalanine, 4-cyano-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
• CAS NO: 298693-79-5
• Molecular Formula: C16H20N2O4
• Molecular Weight: 304.346
• Mol File: 298693-79-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, 4-cyano-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, 4-cyano-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester(298693-79-5)
• EPA Substance Registry System: L-Phenylalanine, 4-cyano-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester(298693-79-5)

Safety Data

• Hazardous Substances Data: 298693-79-5(Hazardous Substances Data)

Upstream product

• 112766-18-4 methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate 
• 151-50-8 potassium cyanide 
• 67-56-1 methanol 
• 131724-45-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid 
• 557-21-1 zinc(II) cyanide 
• 266306-18-7 (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 623-00-7 4-bromobenzenecarbonitrile 
• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 74-83-9 methyl bromide 
• 175844-11-8 methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 

Downstream Products

• 272784-76-6 (S)-methyl 2-amino-3-(4-cyanophenyl)propanoate 
• 945245-48-7 N-tert-butyloxycarbonyl-L-(p-bromomethyl)phenylalanine methyl ester 
• 945245-49-8 N-tert-butyloxycarbonyl-(p-sulfomethyl)-L-phenylalanine methyl ester 
• 266999-30-8 C₁₅H₂₁NO₇S 
• 945245-54-5 N-(fluorenyl-9-methoxycarbonyl)-L-(p-sulfomethyl)phenylalanyl-L-(4-O-benzyl)-aspartic acid α-tert-butyl ester 
• 206060-45-9 N-(fluorenyl-9-methoxycarbonyl)-L-(p-sulfomethyl)phenylalanine 
• 216774-50-4 N-tert-butyloxycarbonyl-(p-hydroxymethyl)-L-phenylalanine methyl ester 
• 1227311-10-5 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyano-2,6-dimethylphenyl)propanoate 
• 623950-05-0 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoate 

Relevant articles and documents

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.

OPIOID RECEPTOR MODULATORS AND PRODUCTS AND METHODS RELATED THERETO

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Mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media

A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2-5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.