1227367-60-3

Upstream product

• 1227185-32-1 C₁₅H₃₀N₆O₄ 
• 99-96-7 4-hydroxy-benzoic acid 
• 773838-08-7 3-(4-hydroxybenzamido)propanoic acid 
• 1280551-80-5 benzyl 3-(4-hydroxybenzamido)propanoate 
• 1227185-30-9 tert-butyl 3,3'-(propane-1,3-diylbis(azanediyl))bis(3-oxopropane-3,1-diyl)dicarbamate 

Downstream Products

• 1227367-59-0 N,N'-(3,7,13,17-tetrathioxo-4,8,12,16-tetraazanonadecane-1,19-diyl)bis(4-hydroxybenzothioamide) 

Relevant academic research and scientific papers

Closthioamide: An unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum

(Chemical Equation Presented) Choose sulfur in an oxygen-free world: Closthioamide (1) was isolated from the anaerobe Clostridium cellulolyticum (see SEM image) after the induction of its biosynthesis with an aqueous soil extract. An unprecedented type of symmetrical natural product in which all building blocks are connected through thioamide linkages, 1 is active against multiresistant staphylococci. It is the only known secondary metabolite from a strictly anaerobic bacterium.

CLOSTHIOAMIDES

This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.

Highly efficient total synthesis of the clostridium-derived anti-MRSA antibiotic closthioamide

The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation. The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient route starting from simple building blocks, involving convergent peptide coupling and polythionation. Copyright