773838-08-7

Usage

Uses

Used in Pharmaceutical Industry:
3-[(4-HYDROXYBENZOYL)AMINO]PROPANOIC ACID is used as an intermediate in the synthesis of antibiotics, specifically for the preparation of closthioamide. Its unique structure likely contributes to the antibiotic's activity against certain bacterial strains, making it a valuable component in the development of new antimicrobial agents to combat drug-resistant infections.
Given the limited information provided, the primary application of 3-[(4-HYDROXYBENZOYL)AMINO]PROPANOIC ACID appears to be in the pharmaceutical industry for antibiotic development. Further research and exploration may reveal additional uses in other industries or applications, such as potential roles in drug delivery systems, therapeutic agents, or as building blocks for other bioactive compounds.

InChI:InChI=1/C10H11NO4/c12-8-3-1-7(2-4-8)10(15)11-6-5-9(13)14/h1-4,12H,5-6H2,(H,11,15)(H,13,14)

Upstream product

• 1280551-80-5 benzyl 3-(4-hydroxybenzamido)propanoate 
• 7377-08-4 N-(4-aminobenzoyl)-B-alanine 
• 122-04-3 4-nitro-benzoyl chloride 
• 59642-21-6 N-(4-nitrobenzoyl)-beta-alanine 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 1227367-60-3 N,N'-(3,7,13,17-tetraoxo-4,8,12,16-tetraazanonadecane-1,19-diyl)bis(4-hydroxybenzamide) 

Relevant academic research and scientific papers

Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones

Thioamide-containing nonribosomal peptides (NRPs) are exceedingly rare. Recently the biosynthetic gene cluster for the thioamidated NRP antibiotic closthioamide (CTA) was reported, however, the enzyme responsible for and the timing of thioamide formation remained enigmatic. Here, genome editing, biochemical assays, and mutational studies are used to demonstrate that an Fe-S cluster containing member of the adenine nucleotide α-hydrolase protein superfamily (CtaC) is responsible for sulfur incorporation during CTA biosynthesis. However, unlike all previously characterized members, CtaC functions in a thiotemplated manner. In addition to prompting a revision of the CTA biosynthetic pathway, the reconstitution of CtaC provides the first example of a NRP thioamide synthetase. Finally, CtaC is used as a bioinformatic handle to demonstrate that thioamidated NRP biosynthetic gene clusters are more widespread than previously appreciated.

Sustainable Synthesis of Balsalazide and Sulfasalazine Based on Diazotization with Low Concentrations of Nitrogen Dioxide in Air

Low concentrations of nitrogen dioxide, which arises as a side product from a range of industrial processes, can effectively be recycled through the diazotization of anilines. The studies reported herein now demonstrate that the removal of nitrogen dioxide from gas streams is even more effective when hydrophilic anilines are used as starting materials. The diazonium salts, which are obtained in this way in up to quantitative yields, can directly be employed in azo coupling reactions, thus opening up an attractive route to the industrially important group of azo compounds.

CLOSTHIOAMIDES

This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.

Highly efficient total synthesis of the clostridium-derived anti-MRSA antibiotic closthioamide

The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation. The antibiotic closthioamide from Clostridium cellulolyticum, the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient route starting from simple building blocks, involving convergent peptide coupling and polythionation. Copyright