122775-92-2Relevant academic research and scientific papers
Modification of Pyridine-3-carboxamide (Nicotinamide) by Radical Substitution
Tada, Masaru,Yokoi, Yurie
, p. 45 - 48 (2007/10/02)
Pyridine-3-carboxamide (1) was reacted with alkyl radicals to give mono-, di-, and tri-alkylated products.The t-butyl radical gives only 6-t-butylpyridine-3-carboxamide (4a).The reactivity decreases in the order of t-butyl, isopropyl, and ethyl radicals.The product 4a reacts further with the 2-phthalimidoethyl radical to give 2- and 4-substituted products 9 and 10, which were transformed into tetrahydronaphthyridinone derivatives 11 and 12.
