122778-95-4

Basic information

• Product Name: Benzofuran, 5-(1,1-dimethylethyl)-2-phenyl-
• CAS NO: 122778-95-4
• Molecular Formula: C18H18O
• Molecular Weight: 250.34
• Mol File: 122778-95-4.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzofuran, 5-(1,1-dimethylethyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 5-(1,1-dimethylethyl)-2-phenyl-(122778-95-4)
• EPA Substance Registry System: Benzofuran, 5-(1,1-dimethylethyl)-2-phenyl-(122778-95-4)

Safety Data

• Hazardous Substances Data: 122778-95-4(Hazardous Substances Data)

Upstream product

• 4922-43-4 dodecyl 1-phenylethenyl sulfide 
• 98-54-4 para-tert-butylphenol 
• 100-42-5 styrene 
• 591-50-4 iodobenzene 
• 253185-03-4 tert-butylbenzene 
• 84563-54-2 bis(4-tert-butylphenyl)iodonium trifluoromethanesulfonate 
• 1620889-21-5 C₂₀H₂₂O₂ 
• 38941-98-9 4-tert-butyl-2-iodophenol 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 1309868-14-1 4-(tertbutyl)-2-(2,2-dibromovinyl)phenol 
• 873-55-2 sodium benzenesulfonate 
• 2996-92-1 phenyl trimethylsiloxane 
• 1236291-48-7 ethyl N-4-(tert-butyl)phenoxyacetimidate 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis of benzofurans from terminal alkynes and iodophenols catalyzed by recyclable palladium nanoparticles supported on N,O-dual doped hierarchical porous carbon under copper- and ligand-free conditions

We herein report that a stable and recyclable heterogeneous catalyst, consisting of Pd nanoparticles supported on N,O-dual doped hierarchical porous carbon derived from naturally available and renewable biomass-bamboo shoots, which allows for highly efficient one-pot tandem reaction of o-iodophenols with terminal alkynes to synthesize biologically active 2-benzofuran derivatives under copper- and ligand-free conditions. The catalyst performed superior catalytic performance compared with the analogous Pd/C and supported on other metal oxides under otherwise identical conditions. A broad set of aryl and alkyl terminal alkynes can be effectively coupled /cyclized with various o-iodophenols to afford their corresponding 2-benzofurans in good to high yields with good tolerance of multiple functional groups. Moreover, the catalyst showed good stability and could be reused several times without significant loss of activity.

CuI catalyzed domino coupling–cyclization of 2-iodo-phenols and 1-alkynes to the synthesis of 2-substituted benzo[b]furans/furo-pyridines

CuI/proline-catalyzed coupling reaction of 2-iodo-phenols with terminal alkynes and the following cyclization process is carried out successively in DMSO at 80 °C. Under this tandem process, 2-substituted benzo[b]furans/furo-pyridines were synthesized in good to excellent yields with a great diversity.

Palladium-Catalyzed Direct Annulation of Benzoic Acids with Phenols to Synthesize Dibenzopyranones

Direct annulation of benzoic acids with phenols via palladium-catalyzed oxidative coupling is reported. Readily available and inexpensive starting materials were used in this novel method to synthesize highly valuable and useful dibenzopyranone scaffolds.